Manchester United will be the first opponents for Pompey Academy’s under-18 side next season.
Andy Awford’s outfit will make the long trip to face the Red Devils on Saturday, August 20 – before hosting Liverpool at the Wellington Sports Ground, Eastleigh a week later.
Pompey will travel to Southampton for the first south coast derby on November 12 , with the return fixture on January 14.
The Blues are in Group A of the Premier Academy League, alongside Arsenal, Charlton, Chelsea, Crystal Palace, Fulham, Ipswich, Norwich, Southampton and West Ham.
Pompey will play each of the sides in their group home and away, as well as 10 matches against sides from other groups.
As well as the matches against Manchester United and Liverpool, the Blues will also face Coventry, Bristol City, MK Dons, Cardiff, Leicester, Tottenham, Reading and Aston Villa.
Pompey Academy 2011/12 fixtures:
Sat Aug 20 Manchester United (A)
Sat Aug 27 Liverpool (H)
Sat Sep 3 Coventry City (H)
Sat Sep 10 Bristol City (A)
Sat Sep 17 Milton Keynes Dons (H)
Sat Sep 24 Charlton Athletic (A)
Sat Oct 1 West Ham United (H)
Sat Oct 8 Fulham (A)
Sat Oct 15 Chelsea (H)
Sat Oct 29 Norwich City (A)
Sat Nov 5 Ipswich Town (H)
Sat Nov 12 Southampton (A)
Sat Nov 19 Arsenal (H)
Sat Dec 3 Crystal Palace (A)
Sat Dec 10 Chelsea (A)
Sat Dec 17 Norwich City (H)
Sat Jan 7 Ipswich Town (A)
Sat Jan 14 Southampton (H)
Sat Jan 21 Arsenal (A)
Sat Jan 28 Crystal Palace (H)
Sat Feb 11 Charlton Athletic (H)
Sat Feb 18 West Ham United (A)
Sat Feb 25 Fulham (H)
Sat Mar 3 Cardiff City (A)
Sat Mar 10 Leicester City (H)
Sat Mar 17 Tottenham Hotspur (H)
Sat Mar 31 Reading (A)
Sat Apr 21 Aston Villa (A)