Pompey will try to put their cup disappointment to one side when they host Oxford in League One this weekend.
And Kenny Jackett’s side are the 5/6 favourites with Sky Bet to return to winning ways at Fratton Park.
The visitors – who have yet to collect a point and currently sit bottom of the standings – can be backed at 7/2, with the draw at 12/5.
Pompey eased to a 3-0 victory in this fixture last season and a repeat of that scenario carries odds of 12/1.
Supporters might instead prefer to take a punt on a 2-1 win for the home side at 15/2 or even a 4-1 triumph at 33/1.
You can also take advantage of a Sky Bet boost, with the Blues coming out on top and both teams scoring moving from 3/1 to 7/2.
Or you could choose to hedge your bets in the group betting market, with a 1-0, 2-0 or 2-1 success at 13/8.
Brett Pitman will be looking to get off the mark and is the 7/2 favourite to net the opener on Saturday.
Elsewhere in the first goalscorer market, Ronan Curtis, David Wheeler and Matt Clarke are on offer at 5/1, 9/1 and 25/1 respectively.
Please gamble responsibly and remember that all odds are subject to change. When the fun stops, stop.
Visit Sky Bet for more great offers and promotions and use this link when you bet to also earn money for Pompey.