Pompey still have a chance – albeit a slim one – of securing a place in the League One play-offs with a couple of games remaining.
But Bury, their opponents on Saturday, saw their fate sealed a couple of weeks ago and will be playing fourth tier football next term.
A home defeat to struggling Northampton was enough to confirm relegation and the Gigg Lane outfit are guaranteed to finish rock bottom.
Shakers striker Ryan Lowe was handed the managerial reins in January, but was not able to succeed where previous bosses Lee Clark and Chris Lucketti failed.
The north-west outfit have secured just one away league victory all season and have managed only six on home soil.
But they do go into Saturday’s contest on the back of successive stalemates at Doncaster and Shrewsbury.
Matt Clarke’s header proved the difference between the sides when they met at Fratton Park just before Christmas.
Pompey were beaten 3-0 in the last Gigg Lane meeting back in 2014, while a last-gasp Wes Fogden goal secured a dramatic 4-4 draw the previous season.
🎥 It was a crazy game on this day in 2014, as #Pompey came from 3-0 down to eventually draw 4-4 with Saturday's opponents @buryfcofficial ⬇️— Portsmouth FC (@officialpompey) April 26, 2018
And the Blues left it late at Gigg Lane, Wes Fogden's equaliser coming in the 93rd minute! pic.twitter.com/oRZaVdsBMQ
Nathan Thompson has recovered from a dead leg suffered against Charlton last week and is available to feature.
But the Blues will be without Stephen Henderson (groin), Christian Oxlade-Chamberlain (leg), Danny Rose (leg), Anton Walkes (hamstring) and Jack Whatmough (groin).
Danny Mayor (ankle) is a doubt for the hosts, who are definitely missing top scorer Jermaine Beckford (knee).
HEAD TO HEAD
Pompey: 12 wins
Bury: 12 wins
At Gigg Lane
Pompey: 3 wins
Bury: 9 wins
Seats can be secured from the Gigg Lane ticket office or at the cash turnstiles (eight and nine in the Main Stand). Click here for more details.
Overseas subscribers can watch the match live by following the same instructions.
ALSO IN LEAGUE ONE
Blackpool v Shrewsbury
Bradford v Southend
Bristol Rovers v Gillingham
Charlton v Blackburn
MK Dons v Scunthorpe
Oldham v Doncaster
Oxford v Rochdale
Peterborough v Fleetwood
Plymouth v Rotherham
Walsall v Northampton
Wigan v AFC Wimbledon