Two sides sitting just outside the play-off places go head-to-head in South Yorkshire on Saturday.
Pompey sit one place – and the same number of points – ahead of their eighth-placed hosts Rotherham.
Fans will no doubt be looking forward to visiting New York Stadium for the very first time, with their last trip to United taking place at Millmoor.
The Blues won 3-2 in October 2002, courtesy of goals from Vincent Pericard, Svetoslav Todorov and Paul Merson, and went on to secure the Division One title.
It was the Millers celebrating victory at Fratton Park earlier in the current campaign, however, with Jon Taylor’s strike enough to secure the points in front of the Sky Sports cameras.
But Paul Warne’s men are without their top scorer, with Kieffer Moore seeing his loan from Ipswich cut short so he could make a permanent switch to Barnsley.
He had notched 13 times in League One during the first half of the season, while their current most prolific frontman, David Ball, has just six goals.
Rotherham are looking to bounce back from a disappointing 2016/17, which saw them finish rock bottom of the Championship – 28 points adrift of safety.
Gareth Evans (hamstring) is not quite fit enough to be able to return to action, while Stuart O’Keefe has undergone surgery on a groin problem that is set to keep him sidelined for 10-12 weeks.
Brandon Haunstrup (knee), Milan Lalkovic (Achilles), Danny Rose (leg) and Jack Whatmough (knee) are also missing.
Rotherham will be without Darren Potter (Achilles), but former Blues players Joe Mattock, Michael Smith and Ryan Williams could all feature.
HEAD TO HEAD
Pompey: 11 wins
Rotherham: 9 wins
Pompey: 3 wins
Rotherham: 7 wins
Seats can be bought from the away ticket office at New York Stadium, although there is a price increase. Click here for more details.
Overseas subscribers can watch the match live by following the same instructions.
ALSO IN LEAGUE ONE
AFC Wimbledon v Blackpool
Bristol Rovers v Bradford
Charlton v Walsall
Fleetwood v Blackburn
Northampton v MK Dons
Oxford v Bury
Peterborough v Oldham
Plymouth v Wigan
Rochdale v Southend
Scunthorpe v Gillingham
Shrewsbury v Doncaster
LAST AWAY MEETING
🎥 | #Pompey have never played a competitive fixture at @OfficialRUFC's New York Stadium, but the last game we contested at the Millers' old Millmoor ground was a memorable one to say the least... ⬇️ pic.twitter.com/MFFkvAi216— Portsmouth FC (@officialpompey) January 18, 2018