The latest chapter in the epic Pompey v Plymouth tale will be written at Fratton Park on Saturday.
A healthy rivalry has built up between the sides in recent years following several epic contests in League Two.
Argyle came out on top in the 2015/16 play-offs, with a last-gasp winner at Home leaving Blues fans heartbroken.
But they had plenty of reason to be cheerful six months ago, as Pompey pipped the Pilgrims to the League Two title on the final day.
Sonny Bradley, Nadir Ciftci, Toumani Diagouraga and Jake Jervis could all feature for Derek Adams’ side against their former club, although Ryan Taylor is currently out injured.
The Devon outfit are in need of points to move away from danger, with Bury currently the only team keeping them off the foot of the table.
But a decent run of form of late has seen them move closer to safety following a disastrous opening to the campaign.
Their worst spell saw 12 games pass without a victory, but Argyle have been beaten in just one of their past seven league outings.
Christian Burgess serves a one-match ban after collecting his fifth yellow card of the season at Peterborough.
Brett Pitman (hamstring) is doubtful for the hosts, while Milan Lalkovic (Achilles), Damien McCrory (knee) and Jack Whatmough (knee) are all out.
Remi Matthews is Plymouth’s only fit goalkeeper, with Kyle Letheren (thigh), Luke McCormick (ankle) and Robbert te Loeke (back) injured.
Former Blues striker Ryan Taylor (ankle) misses out, as do Ryan Edwards (suspension), Jamie Ness (ankle) and Oscar Threlkeld (leg).
Matty Kennedy talks through 2016/17 Sky Bet League Two final day
On the final day of the 2016/17 Sky Bet League Two season, Pompey sealed the division title in dramatic fashion. Matty Kennedy - on loan at Plymouth at the time - provides his take on an unlikely series of events that led to the Blues' dramatic smash-and-grab.
HEAD TO HEAD
Pompey: 26 wins
Plymouth: 24 wins
At Fratton Park
Pompey: 16 wins
Plymouth: 10 wins
Fratton Park is full to capacity for Saturday’s match.
The booths behind the Fratton End will be open from 11am on Saturday to sell tickets for future home games. Click here to find out which fixtures are currently on sale.
Pompey’s ticket office will be open for enquiries and upgrades only, while collections can be made from main reception.
Overseas subscribers can watch the match live by following the same instructions.
ALSO IN LEAGUE ONE
AFC Wimbledon v Walsall
Blackburn v Bristol Rovers
Doncaster v MK Dons
Fleetwood v Blackpool
Gillingham v Oldham
Northampton v Bury
Rochdale v Peterborough
Rotherham v Wigan
Scunthorpe v Charlton
Shrewsbury v Bradford
Southend v Oxford