Pompey have made a perfect start to the League One campaign, with maximum points taken from games against Luton and Blackpool.
But tonight the attention shifts to trying to progress into the second round of the Carabao Cup for the first time in three years.
The Blues lost to Championship opposition at this stage last season, but took Cardiff – who would go on to secure promotion – to extra-time in Wales.
They took the lead through a Sean Morrison own-goal, only for strikes from former Pompey players Nathaniel Mendez-Laing and Greg Halford to turn the tie on its head.
It was a similar story for this evening’s visitors, who also lost to second tier opponents after extra-time, going down 3-1 at home to Brentford.
Neither side has ever lifted the League Cup, although Pompey have reached the quarter-finals on five occasions, most recently in 2010.
AFC Wimbledon have made an encouraging start to the current campaign, following up an opening day win at Fleetwood by drawing with Coventry last Saturday.
Pompey won both of last season’s league meetings, with their 2-0 win at Kingsmeadow preceding a 2-1 Boxing Day triumph at Fratton Park.
Pompey will be without Dion Donohue (groin) and Nathan Thompson (knee), but Conor Chaplin has recovered from a hip problem.
Former Blues winger Andy Barcham is a doubt with a toe injury, but the visitors have no other fitness concerns.
HEAD TO HEAD*
Pompey: 14 wins
Wimbledon: 12 wins
At Fratton Park
Pompey: 9 wins
Wimbledon: 3 wins
*Against Wimbledon and AFC Wimbledon
Seats can still be secured online here or from the Anson Road ticket office. From 5.30pm this evening, they will also be available from the matchday ticket office in Frogmore Road.
Supporters collecting tickets from 5.30pm this evening should visit main reception.
Parking in the North Stand car park is priced just £5 for tonight’s game, with spaces allocated on a first come, first served basis.
The Victory Lounge behind the Fratton End is open to supporters from 5.30pm.
Domestic and overseas iFollow subscribers can listen to live commentary from Andy Moon and Guy Whittingham by signing into their account and visiting the match centre from 7pm this evening.
Please note that for Carabao Cup matches, overseas subscribers will not be able to watch the game live.
ALSO IN CARABAO CUP
(7.45pm kick-off unless stated)
Nottingham Forest v Bury (7.30pm)
Blackpool v Barnsley
Bristol City v Plymouth
Bristol Rovers v Crawley
Cambridge v Newport
Carlisle v Blackburn
Cheltenham v Colchester
Crewe v Fleetwood
Exeter v Ipswich
Grimsby v Rochdale
Leeds v Bolton
Macclesfield v Bradford
Mansfield v Accrington
Middlesbrough v Notts County
Millwall v Gillingham
MK Dons v Charlton
Norwich v Stevenage
Oldham v Derby
Oxford v Coventry
Port Vale v Lincoln
Preston v Morecambe
QPR v Peterborough
Rotherham v Wigan
Scunthorpe v Doncaster
Sheffield United v Hull
Shrewsbury v Burton
Southend v Brentford
Swindon v Forest Green
Tranmere v Walsall
Wycombe v Northampton
Yeovil v Aston Villa
Reading v Birmingham (8pm)
West Bom v Luton (8pm)
Sunderland v Sheffield Wednesday