For the second league game in succession, Pompey are preparing to face a side that have not tasted success this season.
Shrewsbury are currently only being kept off the foot of the table by last week’s vanquished Fratton visitors Plymouth.
Having narrowly missed out on automatic promotion last term and then lost at Wembley in the play-off final, the Shropshire side underwent drastic changes.
Manager Paul Hurst left for Ipswich and took star players Jon Nolan and Toto Nsiala with him to the Championship.
There have been several other departures, including, of course, goalkeeper Craig MacGillivray’s move to the Blues.
New boss John Askey has so far overseen two draws and four defeats in League One, although they have not been beaten by more than a single goal.
The Shrews can take heart from the fact that they have won each of the past five meetings between the teams.
But Pompey will be hoping to end that unwanted record as they chase a fourth successive home league win – something they have not done at the start of a season in 16 years.
Pompey will be without the injured duo of Anton Walkes (groin) and Jack Whatmough (hamstring), but Oli Hawkins (hamstring) could be available.
Top scorer Ronan Curtis also misses out, as he is away on international duty with Republic of Ireland under-21s.
James Bolton (hamstring) and Abo Eisa (knee) will be absent for Shrewsbury, but Josh Emmanuel could make his debut.
HEAD TO HEAD
Pompey: 12 wins
Shrewsbury: 9 wins
At Fratton Park
Pompey: 10 wins
Shrewsbury: 2 wins
Seats can be bought online here or from the Anson Road ticket office.
On the day of the game, they can be bought (subject to availability) from both ticket offices from 9am, with collections available from main reception.
Parking behind the North Stand is priced £10 per car and available on a first come, first served basis.
The Victory Bar behind the Fratton End will be open for supporters from 12pm.
Because the game takes place during an international week, supporters in the UK and Ireland can watch the action live, with commentary and graphics. It is priced £10 for a match pass.
Domestic subscribers will, as usual, be able to listen to listen to live commentary from Andy Moon and Guy Whittingham by signing into their account and visiting the match centre from 2pm. Please note that subscribers will still need to purchase a match pass in order to watch the game live.
Overseas subscribers and match pass holders can watch the action, with commentary starting from around 10 minutes before kick-off.
ALSO IN LEAGUE ONE
Kick-off 3pm unless stated
Bristol Rovers v Plymouth (1.30pm)
Accrington v Burton
Barnsley v Walsall
Blackpool v Bradford
Charlton v Wycombe
Doncaster v Luton
Gillingham v AFC Wimbledon
Scunthorpe v Rochdale
Southend v Peterborough
Sunderland v Fleetwood
Oxford v Coventry (12pm)