The Fratton faithful will be hoping to unwrap a belated Christmas present of three points on Boxing Day.
But Pompey will have to see off the League One leaders to ensure the festive feeling does not fall flat.
Wycombe are the surprise pacesetters – at least according to the bookies – and currently hold a seven-point advantage over nearest challengers Peterborough.
It means that whatever happens over the next few days, they will definitely be in top spot at the start of 2020.
Gareth Ainsworth’s men have the meanest defence in the division, with just 15 goals conceded in 21 games.
Their best form has come at Adams Park, however, and – like the Blues – they are unbeaten on home soil.
But the Chairboys have only won three games on their travels and were beaten 1-0 at Oxford on Saturday.
Both sides were reduced to 10 men when Wanderers narrowly won a poor quality contest back in September, while last season’s Fratton meeting ended 2-2.
Ross McCrorie will miss Pompey’s Christmas fixtures after limping off with a hamstring injury on Saturday.
Lee Brown (Achilles) and Brandon Haunstrup (meniscus) will also be out for the rest of 2019 after undergoing operations.
Bryn Morris (groin) is still in the treatment room, while Jack Whatmough is not yet ready for selection following his knee problem.
Wycombe striker Adebayo Akinfenwa serves a one-match ban after getting sent off at the weekend, but former Blues loanee David Wheeler could feature.
HEAD TO HEAD
Pompey: 4 wins
Wycombe: 4 wins
At Fratton Park
Pompey: 2 wins
Wycombe: 2 wins
Fratton Park is full to capacity for Thursday’s game, but fans can check the eticketing site to see if any seats become available via the ticket exchange.
Referee: John Busby
Assistants: Simon Shaw and Gregory Read
Fourth Official: Adrian Quelch
Supporters in the UK and Ireland can watch the action live, with multiple cameras, commentary, replays and graphics. It is priced £10 for a match pass.
Please note that domestic subscribers will still need to purchase a match pass in order to watch the game live.
ALSO IN LEAGUE ONE
All games kick-off at 3pm
Blackpool v Accrington
Bristol Rovers v AFC Wimbledon
Burton v Tranmere
Ipswich v Gillingham
Oxford v Lincoln
Peterborough v Doncaster
Rochdale v Fleetwood
Shrewsbury v Rotherham
Southend v MK Dons
Sunderland v Bolton
LAST FRATTON MEETING