Pompey are looking to start another winning run following their narrow midweek loss at Coventry.
Prior to that, Kenny Jackett’s side had enjoyed a club record nine victories in succession in all competitions.
This weekend sees them hosts a Shrewsbury side who have not tasted success in the league since just before Christmas.
Their only triumph in that time was an FA Cup defeat of Championship side Bristol City, while they then held European champions Liverpool to a draw before exiting in the Anfield replay.
In the league, however, the Shropshire outfit are enduring a slump that has seen them fall to 17th in the table.
But there is a still a comfortable gap of 12 points between Sam Ricketts’ men and the relegation places.
They were beaten 2-0 on home soil by Accrington on Tuesday night and head to the south coast with just three away league wins under their belt all season.
It was the Shrews who came out on top when the sides met on the opening day of the campaign, though.
A stunning strike from Ryan Giles settled a fairly cagey contest, while Ross McCrorie was dismissed on his debut late on.
Andy Cannon is still sidelined with the glute injury that has kept him out of the past two games, although is close to a return.
Bryn Morris is running outside again as he continues to step up his recovery from a long-term groin problem.
Ollie Norburn is set to miss the rest of the season for Shrewsbury after injuring his knee in the FA Cup draw with Liverpool.
The visitors will also be without Josh Vela (thigh), Brad Walker (hamstring) and Shaun Whalley (hamstring).
HEAD TO HEAD
Pompey: 13 wins
Shrewsbury: 10 wins
At Fratton Park
Pompey: 10 wins
Shrewsbury: 2 wins
Pompey have sold out of seats for the game, with supporters advised to check if any become available via the ticket exchange.
Referee: Lee Swabey
Assistants: Leigh Crowhurst and Mark Derrien
Fourth Official: Stephen Brown
Overseas subscribers and match pass holders can watch the action and commentary will begin from around 10 minutes before kick-off.
ALSO IN LEAGUE ONE
All games kick-off at 3pm
Accrington v Lincoln
Bolton v Wycombe
Bristol Rovers v Blackpool
Fleetwood v Peterborough
Gillingham v Doncaster
Ipswich v Burton
Oxford v Sunderland
Rochdale v Tranmere
Rotherham v AFC Wimbledon
Southend v Coventry
LAST FRATTON MEETING