Pompey switch their focus back to the League One promotion race after progressing in two other competitions over the past week.
Kenny Jackett’s side have home ties against Barnsley and Scunthorpe in the FA Cup and Leasing.com Trophy to look forward to later this month.
But it is the quest to climb the table that takes centre stage on Saturday, as AFC Wimbledon head to Fratton Park.
The Blues are just one point outside the play-off spots with half their fixtures remaining – and only six adrift of second position.
Their opponents, meanwhile, are more concerned with events at the other end of the division and trying to pull away from the danger zone.
Glyn Hodges is the man tasked with trying to avoid taking the battle to beat the drop to the final day for a second successive season.
He began the campaign as assistant manager, but took the top job after Wally Downes was charged by The FA for a breach of betting regulations.
Pompey were narrowly beaten when they visited Kingsmeadow back in October, courtesy of a last-gasp goal from Terell Thomas.
Cameron McGeehan could be handed his Pompey debut after completing a loan switch from Barnsley earlier in the week.
Fellow new signings Steve Seddon and Reeco Hackett-Fairchild will also be hoping to make their Fratton bows.
Lee Brown (Achilles), Ross McCrorie (hamstring), Bryn Morris (groin) and Ryan Williams (groin) are all still absent.
Brandon Haunstrup (meniscus) and Jack Whatmough (knee) are both back in training, but not ready to feature on Saturday.
AFC Wimbledon’s new loan defender Mads Bech Sorensen could make his first appearance after arriving from Brentford.
The visitors will be without Kwesi Appiah (ankle), Paul Kalambayi (ankle), Will Nightingale (hip), Adam Roscrow (thigh) and Anthony Wordsworth (calf).
Cameron McGeehan pre-AFC Wimbledon
Cameron McGeehan chats for the first time since joining Pompey on loan earlier in the week. The Barnsley midfielder has joined the Blues until the end of the season, and discussed his Portsmouth family connections as well as his experience getting promoted from League One.
HEAD TO HEAD*
Pompey: 16 wins
Wimbledon: 14 wins
At Fratton Park
Pompey: 10 wins
Wimbledon: 4 wins
*Includes matches against Wimbledon FC
Pompey fans can secure seats online here. Subject to availability they will also be available to buy from both ticket offices from 9am on Saturday.
Referee: Trevor Kettle
Assistants: John Flynn and Alasdair Ross
Fourth Official: Robert Dabbs
Overseas subscribers and match pass holders can watch the action and commentary will begin from around 10 minutes before kick-off.
ALSO IN LEAGUE ONE
All games kick-off at 3pm
Bristol Rovers v Doncaster
Burton v Fleetwood
Coventry v MK Dons
Ipswich v Accrington
Oxford v Rotherham
Peterborough v Gillingham
Rochdale v Bolton
Shrewsbury v Lincoln
Southend v Tranmere
Sunderland v Wycombe
LAST FRATTON MEETING