Despite not playing last weekend and losing on Tuesday night, Pompey remain fourth in the League One standings.
But they will be looking for an instant return to winning ways against Blackpool in order to keep pace with the top two.
Their opponents are 14th in the table and eight points adrift of the play-off places, with as many as three games in hand on the sides around them.
Neil Critchley’s men have won three of their past four fixtures – a run that began with a 5-0 rout of Wigan.
That result is one of four victoriess on the road for the Seasiders, who have also collected a maximum haul at Burton, Peterborough and neighbours Fleetwood.
They also caused an FA Cup upset last month by knocking out Premier League side West Brom on penalties at Bloomfield Road, only to exit at the hands of Brighton in the fourth round.
The Covid-19 pandemic meant that there was no south coast meeting between the teams last season.
Blackpool won 1-0 on their most recent visit to Fratton Park in January 2019 and also triumphed by the same scoreline on their own patch a few months ago.
Pompey have no new injury concerns, although Alex Bass (leg) and Michael Jacobs (hamstring) are still sidelined.
Blackpool defender Marvin Ekpiteta will miss out after being sent for a scan on a troublesome hamstring problem.
Keshi Anderson (knee), Daniel Gretarsson (hamstring) and CJ Hamilton (hamstring) are all unable to feature, while Gary Madine (groin) is a doubt.
HEAD TO HEAD
Pompey: 22 wins
Blackpool: 28 wins
At Fratton Park
Pompey: 15 wins
Blackpool: 11 wins
Referee: Sam Allison
Assistants: Justin Amey and Simon Shaw
Fourth Official: Adrian Tranter
Supporters in the UK can watch the action live – with graphics, commentary and replays – by purchasing a match pass for £10.
Please note that subscribers based in the UK and Ireland will still need to purchase a match pass in order to watch the game live.
There will be post-match reaction on the website and our official YouTube channel, with highlights to follow on Sunday.
ALSO IN LEAGUE ONE
Games kick-off at 3pm unless stated
Gillingham v Bristol Rovers (1pm)
Accrington v Shrewsbury
Burton v Sunderland
Doncaster v Hull
Fleetwood v Charlton
Ipswich v Oxford
MK Dons v Northampton
Peterborough v AFC Wimbledon
Rochdale v Plymouth
Swindon v Crewe
Wigan v Lincoln