Pompey’s promotion charge has stuttered recently and they are currently seven points adrift of second place.
So Kenny Jackett’s side will be looking to get things back on a track against a Northampton side who were propping up the rest of the division at the beginning of the week.
But the Cobblers should be in confident mood following Tuesday night’s home victory over mid-table Plymouth.
A Ryan Watson brace brought to an end their 11-match winning run and led to a rise of two spots in the standings.
It means that the club are now just a single point shy of the safety mark, with 14 games still left to play.
Poor form led to the dismissal of manager Keith Curle last month, while it was recently announced that caretaker boss Jon Brady will remain in that position for the remainder of the season.
He will be hoping to ensure Northampton do not make an immediate return to League Two, having beaten Exeter at Wembley in last June’s play-off final.
The Blues were beaten 3-1 – with Matty Kennedy on target – on their most recent visit to Sixfields Stadium back in September 2017.
But Pompey triumphed 4-0 when the sides met on the south coast earlier in the current campaign, courtesy of a John Marquis double and goals from Ronan Curtis and Marcus Harness.
James Bolton (ankle) and Michael Jacobs (hamstring) will both require fitness tests after recently returning to training.
Alex Bass has suffered a recurrence of his hairline foot fracture and Callum Johnson (calf) is still sidelined.
Northampton will be without defenders Cian Bolger (hip) and Alan Sheehan (calf), while on-loan Pompey midfielder Bryn Morris cannot appear against his parent club.
VIEW FROM THE DRESSING ROOM
Read the thoughts of Kenny Jackett ahead of the game.
HEAD TO HEAD
Pompey: 20 wins
Northampton: 10 wins
Pompey: 6 wins
Northampton: 7 wins
Referee: Andy Haines
Assistants: Darren Wilding and Leigh Crowhurst
Fourth Official: Paul Stonier
Supporters in the UK can watch the action live – with graphics, commentary and replays – by purchasing a match pass for £10.
Please note that subscribers based in the UK and Ireland will still need to purchase a match pass in order to watch the game live.
There will be post-match reaction on the website and our official YouTube channel, with highlights to follow on Sunday.
Please note that current BBC guidelines mean commentators are not allowed to travel outside of their regions for games.
The BBC Radio Solent team will still be providing commentary from their studio, but there might be a slight delay between the pictures and the audio.
ALSO IN LEAGUE ONE
Games kick-off at 3pm unless stated
Gillingham v Ipswich (1pm)
Accrington v Swindon
Blackpool v AFC Wimbledon
Burton v Peterborough
Doncaster v Plymouth
Hull v Bristol Rovers
Lincoln v Crewe
Oxford v Charlton
Shrewsbury v Fleetwood
Sunderland v Rochdale
Wigan v MK Dons