Pompey and West Ham U21s have already made sure of their place in the last 32 of the Papa John’s Trophy.
But top spot in Southern Group A is still up for grabs when the teams meet at Fratton Park this evening (7pm kick-off).
Whoever secures victory – or a penalty shoot-out bonus point – will enjoy home advantage in the next stage of the competition.
Both sides have already seen off Colchester and Essex, with the two Essex outfits also facing off tonight to avoid the wooden spoon.
Kenny Jackett’s men are, of course, the trophy holders, having beaten Sunderland on penalties on a dramatic day at Wembley in March 2019.
They also made the final of last season’s competition and are still waiting to discover a new date for that postponed clash with Salford.
Their next opponents did not make it out of their group in 2019/20, with Dmitri Halajko’s youngsters bowing out on goal difference.
The two clubs have never previously met in the EFL Trophy and last clashed in the Championship, with the Hammers narrowly winning both encounters during the 2011/12 campaign.
Pompey are set to field a young side, with third year scholars Harry Kavanagh, Alfie Stanley and Eoin Teggart among those who could feature.
Jordy Hiwula could also make his full debut, having signed a short-term deal at Fratton Park last month.
The Blues are without the injured quartet of Lee Brown (hamstring), Andy Cannon (groin), Michael Jacobs (knee) and Jack Whatmough (hamstring).
Competition rules state that the visitors must field a side containing at least six players aged 21 or under.
VIEW FROM THE DRESSING ROOM
Read the thoughts of Kenny Jackett ahead of the game.
HEAD TO HEAD*
Pompey: 14 wins
West Ham: 15 wins
At Fratton Park
Pompey: 9 wins
West Ham: 7 wins
*Games against West Ham's first team
Referee: Kevin Johnson
Assistants: Adam Ricketts and Gareth Viccars
Fourth Official: Richard Morris
Supporters can watch the action live (please note coverage will be provided by a single camera) by purchasing a match pass for £10.
Please note that subscribers based in the UK and Ireland will still need to purchase a match pass in order to watch the game live.
ALSO IN EFL TROPHY
Games kick-off at 7pm unless stated
Gillingham v Arsenal U21 (5.30pm)
Cheltenham v Norwich U21 (6pm)
Crewe v Shrewsbury (6pm)
Barrow v Accrington
Burton v Fulham U21
Cambridge v Peterborough
Charlton v Leyton Orient
Colchester v Southend
Crawley v Ipswich
Doncaster v Wolves U21
Forest Green v Swindon
Grimsby v Leicester U21
Harrogate v Hull
Plymouth v Newport
Port Vale v Liverpool U21
Rochdale v Salford
Scunthorpe v Mansfield
Walsall v Oxford
Bradford v Oldham (7.30pm)
Fleetwood v Sunderland (7.45pm)
Tranmere v Wigan (6.30pm)
Blackpool v Leeds U21
MK Dons v Southampton U21
PREVIOUSLY IN EFL TROPHY