Pompey saw their eight-match unbeaten run come to an end with a narrow defeat at Plymouth earlier in the week.
So they will be keen to get their play-off quest back on track when Wycombe visit the south coast on Saturday (3pm kick-off).
The Chairboys are also battling it out for a place in the end of season lottery, currently sitting a single point behind sixth-placed Sunderland.
Jason McCarthy’s strike deep into stoppage-time earned them a valuable victory against Fleetwood on home soil on Tuesday night.
It means that Gareth Ainsworth’s men have not lost any of their past four fixtures – a sequence that includes three successes and a draw with summit sitters Rotherham.
They are searching for an instant return to the Championship after suffering relegation on the final day of last season.
A depleted Pompey side emerged 1-0 winners when the sides met at Adams Park back on November.
Marcus Harness bundled home the only goal in the second half after Alex Bass had kept out a Joe Jacobson penalty.
The most recent Fratton Park contest took place on Boxing Day on 2019, as Ben Close and Ronan Curtis found the target to provide some festive cheer for the Blues.
Pompey will welcome Marcus Harness back to the squad after the forward completed a three-match suspension.
But Kieron Freeman (ankle), Reeco Hackett (knee), Jayden Reid (knee) and Shaun Williams (back) remain sidelined.
HEAD TO HEAD
Pompey: 6 wins
Wycombe: 4 wins
At Fratton Park
Pompey: 3 wins
Wycombe: 2 wins
All available tickets have sold out for Saturday’s game and no more will be made available.
Covid certification is no longer required to attend, but Portsmouth Football Club respectfully ask all supporters to adhere to the Code of Conduct to ensure an enjoyable and safe matchday experience for all.
A matchday magazine will be available to purchase from sellers around the ground, online from the memorabilia store, in the club shop, the Victory Bar and selected kiosks.
The Victory Bar will be open for Pompey fans from midday on Saturday.
Referee: Benjamin Speedie
Assistants: Damith Bandara and Greg Read
Fourth Official: Kevin Howick
Overseas subscribers and match pass holders can watch all the action live, with accompanying commentary.
There will be post-match reaction on the website and our official YouTube channel, with highlights to follow on Sunday.
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ALSO IN LEAGUE ONE
All games kick-off at 3pm
Cambridge v MK Dons
Charlton v Burton
Cheltenham v AFC Wimbledon
Crewe v Bolton
Fleetwood v Doncaster
Gillingham v Sheffield Wednesday
Lincoln v Sunderland
Oxford v Ipswich
Plymouth v Accrington
Rotherham v Shrewsbury
Wigan v Morecambe
LAST FRATTON MEETING