Pompey halted their losing run by claiming a dramatic draw with Plymouth at Fratton Park earlier in the week.
Now the challenge is to make a return to winning ways when they visit Charlton on Saturday (3pm kick-off).
There were plenty of arrivals and departures at The Valley over the summer, with the squad taking some time to gel.
The Addicks have secured a solitary League One victory so far this season – a 2-0 success over Crewe – and are currently sitting just inside the drop zone.
They were also in action on Tuesday night, but let slip a one-goal lead and had to settle for a point at Gillingham.
Nigel Adkins is in the hot-seat after replacing Lee Bowyer – who left to take charge of Birmingham – in March.
They were sitting in sixth spot when he arrived, but despite just one loss in the final 10 games, they missed out on the play-offs on goal difference.
Both sides won on the road in last season’s meetings, with Pompey securing an impressive 3-1 triumph in the capital.
Michael Jacobs, Tom Naylor and Andy Cannon were on target for Kenny Jackett’s men in a game that was delayed by three days because of a waterlogged pitch.
Connor Ogilvie could return from a quad injury to feature, but skipper Clark Robertson (hip) is set for a lengthy spell on the sidelines after seeing a specialist.
Forward Jayden Reid (knee) and full-back Liam Vincent (shin) are also long-term absentees for the Blues.
The Addicks will be without Jake Forster-Caskey (knee), Ryan Inniss (thigh) and Ronnie Schwartz (calf).
Former Pompey players Craig MacGillivray, Jason Pearce and Jayden Stockley are all expected to be involved for the hosts.
HEAD TO HEAD
Pompey: 46 wins
Charlton: 37 wins
Pompey: 19 wins
Charlton: 20 wins
Pompey have sold their full allocation of tickets, so please do not travel if you do not have one. Click here for information about collections.
Referee: Antony Coggins
Assistants: Geoffrey Russell and Kevin Howick
Fourth Official: Adrian Tranter
Domestic iFollow subscribers can listen to live commentary from Andrew Moon and Guy Whittingham by signing into their account and visiting the match centre from around 2.45pm on Saturday.
Overseas subscribers and match pass holders can watch the action and commentary will begin from around 10 minutes before kick-off.
There will be post-match reaction on the website and our official YouTube channel, with highlights to follow on Sunday.
ALSO IN LEAGUE ONE
All games kick-off at 3pm
Burton v Lincoln
Cambridge v Fleetwood
Ipswich v Sheffield Wednesday
MK Dons v Wycombe
Morecambe v Accrington
Oxford v Gillingham
Plymouth v Doncaster
Rotherham v Crewe
Shrewsbury v AFC Wimbledon
Sunderland v Bolton
Wigan v Cheltenham