Pompey require a win to keep their fading play-off hopes alive when they visit Oxford this evening (7.45pm kick-off).
And their opponents are in an even more desperate need for points as they try to keep their heads above water.
United are currently sitting 20th in the League One standings, with goal difference the only factor keeping them out of the drop zone.
You have to go all the way back to January to find their last victory – against an Ipswich side currently vying for the title.
Oxford are currently on a 15-match winless run, with Karl Robinson’s five-year tenure coming to an end a couple of months ago.
He was replaced by Liam Manning, who helped steady the ship slightly by overseeing a run of four successive draws that ended with Saturday’s narrow home defeat to Bolton.
And there will, of course, be a familiar face in the away dug-out, with John Mousinho leaving his player/coach with United to take charge of Pompey early in 2023.
It finished 1-1 when the sides met on the south coast earlier in the season, as Colby Bishop cancelled out Kyle Joseph’s opener.
But United triumphed 3-2 in last term’s controversial Kassam Stadium contest – which Mousinho featured in – as the 10-man Blues conceded two late goals.
Ronan Curtis (knee), Jayden Reid (knee) and Zak Swanson (groin) remain sidelined, while Joe Morrell serves the third game of a four-match ban.
Tom Lowery missed the trip to Shrewsbury with a minor knee problem and Tuesday’s match probably comes too soon for the midfielder.
Sam Baldock (knee), Billy Bodin (hamstring), James Henry (hamstring) and Stephan Negru (face) are all missing for the hosts.
HEAD TO HEAD
Pompey: 27 wins
Oxford: 24 wins
On the road
Pompey: 9 wins
Oxford: 19 wins
Pompey fans will not be able to purchase tickets at the ground this evening.
Click here to read a guide to visiting the Kassam Stadium that has been produced by the home club.
Referee: Declan Bourne
Assistants: Mark Derrien and Mark Pottage
Fourth Official: Gareth Viccars
Domestic iFollow subscribers can enjoy audio commentary from Andrew Moon and Guy Whittingham as usual, but will need to purchase a match pass if they want to watch the game.
There will be post-match reaction on the website and our official YouTube channel, with highlights to follow on Wednesday.
ALSO IN LEAGUE ONE
All games kick-off at 7.45pm
Accrington v Peterborough
Bristol Rovers v Sheffield Wednesday
Burton v Bolton
Cambridge v Wycombe
Exeter v Derby
Forest Green v Fleetwood
Ipswich v Port Vale
Lincoln v Barnsley
MK Dons v Charlton
Shrewsbury v Plymouth