Last week saw Pompey win twice on the road, knocking Cardiff out of the Carabao Cup before enjoying league success at Cheltenham.
Now they will try to transfer that form back to Fratton Park for successive home games, starting with the visit of Cambridge this evening (7.45pm kick-off).
Mark Bonner’s men have also made a bright start to the current campaign, winning two of their opening three League One matches.
An opening day defeat of MK Dons was followed by Saturday’s victory over Exeter, while United were only beaten by a fine stoppage-time strike at Oxford.
And, like the Blues, they saw off Championship opposition to progress in the cup, seeing off Millwall to set up a second round clash with top-flight Southampton.
Bonner has enjoyed plenty of success since working his way up the Abbey Stadium coaching ranks and being appointed head coach at the start of 2020.
He guided the club to promotion in his first full season in charge, while they finished 14th last term and knocked Newcastle out of the FA Cup.
Pompey have an excellent record in meetings between the two teams, but failed to beat Cambridge in any of the three 2021/22 contests.
Pompey will be waiting on the fitness of Denver Hume, Joe Morrell and Clark Robertson as they step up their returns to full fitness, while Jayden Reid (hamstring) is absent.
Fratton academy graduates Brandon Haunstrup – who joined Cambridge earlier in the summer – and Adam May will be hoping to feature against their former club.
HEAD TO HEAD
Pompey: 14 wins
Cambridge: 3 wins
At Fratton Park
Pompey: 8 wins
Cambridge: 1 win
Limited seating is still available to buy online here or from the Anson Road ticket office. Supporters can also visit the booth behind the Fratton End this evening.
If you are attending the game, click here to read our matchday guide on what is happening around the ground.
Referee: Chris Pollard
Assistants: Ryan Whitaker and Adam Ricketts
Fourth Official: Kevin Morris
Domestic iFollow subscribers can also enjoy audio commentary from Andrew Moon and Mark Kelly as usual, but will need to purchase a match pass if they want to watch the game.
There will be post-match reaction on the website and our official YouTube channel, with highlights to follow on Wednesday.
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ALSO IN LEAGUE ONE
All games kick-off at 7.45pm
Barnsley v Bristol Rovers
Bolton v Morecambe
Burton v Ipswich
Charlton v Plymouth
Exeter v Wycombe
Fleetwood v Cheltenham
Forest Green v Accrington
MK Dons v Port Vale
Oxford v Lincoln
Peterborough v Sheffield Wednesday
Shrewsbury v Derby