It is the start of a new era at Fratton Park, with head coach John Mousinho taking charge for the first time.
A little over 24 hours after being unveiled as the new Blues boss, he will be trying to lead them to victory against Exeter (3pm kick-off).
The former Oxford coach and player will also want to arrest a slide in form that has seen Pompey winless in League One since October.
It means they have fallen to 15th in the table – albeit with up to four games in hand on other sides – and are five places below their next opponents.
The Grecians have reacted well to life back at this level after claiming the runners-up spot in League Two last term.
They have had to recover from losing boss Matt Taylor to Rotherham, with former Scotland international Gary Caldwell now in the dug-out.
And City head to Portsea Island on a four-match unbeaten run that has seen them win their two most recent away contests.
It finished goalless when the sides met in Devon on Boxing Day, but the last Fratton contest was a more memorable affair.
Kenny Jackett’s men netted twice in stoppage-time to seal a dramatic 3-2 win that booked a place at Wembley in the 2020 EFL Trophy final.
A minute's applause will be held before kick-off to pay tribute to former Pompey defender Anton Walkes, who died earlier this week at the age of 25.
We will also remember two other members of the Blues family and fans are invited to join in with a minute's applause for Ace Rewcastle on eight minutes and Steve McLenaghan on 52 minutes.
Marlon Pack has returned from suspension, but Pompey remain without Tom Lowery (hamstring), Jay Mingi (knee), Joe Rafferty (stomach), Jayden Reid (knee) and Clark Robertson (hip).
Exeter will be without Josh Coley (groin), Sam Stubbs (knee) and Kyle Taylor (knee), while there are fitness doubts over Kegs Chauke.
VIEW FROM THE DRESSING ROOM
HEAD TO HEAD
Pompey: 15 wins
Exeter: 6 wins
At Fratton Park
Pompey: 9 wins
Exeter: 4 wins
Referee: Ollie Yates
Assistants: Paul Yates and Joseph Stokes
Fourth Official: Adrian Tranter
Overseas subscribers and match pass holders can watch all the action live, with accompanying commentary.
There will be post-match reaction on the website and our official YouTube channel, with highlights to follow on Sunday.
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ALSO IN LEAGUE ONE
All games kick-off at 3pm
Barnsley v Accrington
Derby v Bolton
Forest Green v MK Dons
Lincoln v Burton
Oxford v Ipswich
Peterborough v Charlton
Plymouth v Cheltenham
Sheffield Wednesday v Fleetwood
Shrewsbury v Cambridge
LAST FRATTON MEETING