Pompey ended the 2021/22 season with a damp squib defeat to Sheffield Wednesday at Hillsborough.
And they will be back there exactly three months later to get the new campaign underway on Saturday (3pm kick-off).
The Owls were celebrating on that day at the end of April, with the win earning them a spot in the play-offs.
Their joy was short-lived, however, with a dramatic two-legged defeat to Sunderland scuppering their hopes of reaching the Championship.
A stoppage-time strike from Patrick Roberts in Yorkshire ensured it was the Black Cats who reached Wembley.
It was the first time that the sides had been in the same division since Pompey romped to the second tier title in 2002/03.
They triumphed 3-1 at Hillsborough that season, courtesy of Svetoslav Todorov’s brace and a goal for Gary O’Neil.
It finished 0-0 at Fratton Park last term, with the hosts not able to capitalise on Massimo Luongo’s dismissal midway through the second half.
There are nine new signings hoping to make their competitive Pompey debuts – although Marlon Pack did play a couple of games during his first spell at the club.
Colby Bishop, Josh Griffiths, Michael Morrison, Josh Oluwayemi, Joe Pigott, Joe Rafferty, Dane Scarlett and Zak Swanson will all be hoping to feature.
Sheffield Wednesday have also been busy over the summer, with former Blues striker Michael Smith among their signings.
HEAD TO HEAD
Pompey: 27 wins
Sheffield Wednesday: 27 wins
Pompey: 9 wins
Sheffield Wednesday: 18 wins
There will be a limited number of tickets available to buy (cash only) from the away turnstiles at Hillsborough on Saturday.
Supporters collecting tickets should visit ‘Gate 6’, which is located next to the away turnstiles.
Fans should note that strikes will affect several train operators on Saturday, so please check before you travel.
Referee: Sebastian Stockbridge
Assistants: Oliver Bickle and Declan Ford
Fourth Official: Scott Simpson
Overseas subscribers and match pass holders can watch all the action live, with accompanying commentary.
There will be post-match reaction on the website and our official YouTube channel, with highlights to follow on Sunday.
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ALSO IN LEAGUE ONE
All games kick-off at 3pm
Accrington v Charlton
Bristol Rovers v Forest Green
Cambridge v MK Dons
Cheltenham v Peterborough
Derby v Oxford
Ipswich v Bolton
Lincoln v Exeter
Morecambe v Shrewsbury
Plymouth v Barnsley
Port Vale v Fleetwood
Wycombe v Burton