A lot has changed since Pompey were originally supposed to make the long trip to Oakwell.
The contest was postponed in September following the sad death of Her Majesty Queen Elizabeth II and will finally take place this evening (7.45pm kick-off).
Six months ago, the Blues were second in the table following an unbeaten start to the season, with the Tykes in 10th.
That position is now occupied by the south coast side, however, and they have a different man in charge.
But John Mousinho has overseen an upturn in form and Pompey head to South Yorkshire in the hunt for a fourth successive victory.
It is sure to be a difficult test against Michael Duff’s men, who are sixth in the standings and have opened up a six-point gap on Wycombe in seventh.
And with at least one game in hand on all the sides around them, the Reds look well placed to at least claim a play-off spot.
That would be most welcome after a 2021/22 campaign that saw them finish rock bottom of the Championship.
This is the second meeting between the teams in just over a month, with a late Liam Kitching goal cancelling out Colby Bishop’s effort at Fratton Park.
The most recent Oakwell contest also finished 1-1, as Gareth Evans found the target for Pompey back in December 2018.
Ronan Curtis will miss the rest of the season after suffering an ACL injury, with Jayden Reid (knee) the other long-term absentee.
Marlon Pack (knee), Clark Robertson (hip) and Zak Swanson (groin) are all still missing, while the game could come too soon for Jay Mingi (knee).
Matty Wolfe (knee) is sidelined for Barnsley, who also have doubts over keeper Brad Collins (quad), but Luca Connell should be available after recovering from illness.
VIEW FROM THE DRESSING ROOM
Read the thoughts of John Mousinho ahead of the game.
HEAD TO HEAD
Pompey: 22 wins
Barnsley: 18 wins
On the road
Pompey: 7 wins
Barnsley: 13 wins
Referee: Marc Edwards
Assistants: Hristo Karaivanov and Richard Woodward
Fourth Official: Steven Rushton
Domestic iFollow subscribers can enjoy audio commentary from Andrew Moon and Guy Whittingham as usual, but will need to purchase a match pass if they want to watch the game.
There will be post-match reaction on the website and our official YouTube channel, with highlights to follow on Wednesday.
ALSO IN LEAGUE ONE
Games kick-off at 7.45pm unless stated
Cambridge v Morecambe
Cheltenham v Lincoln
Ipswich v Accrington
Peterborough v Shrewsbury
Wycombe v Fleetwood
Plymouth v Derby (8pm)