Pompey will look to secure cup progress for the second time in a week when they host MK Dons on Saturday (3pm kick-off).
They enjoyed an impressive victory at Ipswich on Tuesday night to reach the last 16 of the Papa Johns Trophy.
Now the higher profile prize of a spot in the third round of the Emirates FA Cup – where the top two tiers join the competition – is at stake.
Both sides saw off sixth tier outfits to reach this stage, with the Blues battling from behind to win at Hereford, while their opponents trounced Taunton 6-0 on home soil.
The Dons have made a slow start to the League One campaign and currently sit inside the relegation places, heading a bunch of four clubs with just 14 points.
But they have enjoyed the other competitions, also remaining in the Papa Johns Trophy and with a Carabao Cup clash against top-flight Leicester to look forward to next month.
Saturday will be the first ever FA Cup meetings between the sides, although there have been plenty of league contests in recent years.
It was the club from Buckinghamshire who came out on top in both of last season’s fixtures, winning 1-0 at Stadium MK and 2-1 on the south coast.
In the event of a draw after 90 minutes on Saturday, a replay will be held at Stadium MK.
Pompey are still without Michael Jacobs (hamstring), Tom Lowery (hamstring), Joe Rafferty (stomach), Jayden Reid (knee) and Louis Thompson (leg).
Joe Morrell is away on World Cup duty with Wales, while the Blues are waiting to discover whether Owen Dale and Dane Scarlett will be given permission to feature by their parent clubs.
MK Dons also have Matt Smith away with the Welsh in Qatar, with Joshua Kayode (knee) also absent.
HEAD TO HEAD
Pompey: 4 wins
MK Dons: 4 wins
At Fratton Park
Pompey: 3 wins
MK Dons: 1 win
Referee: Sunny Gill
Assistants: Andy Bennett and Declan O’Shea
Fourth Official: Robert Ablitt
Pompey fans can secure their seat online here or by visiting the Anson Road ticket office.
They will also be sold from the ticket office and Fratton End booth on Saturday, but there is an increase in prices.
FA Cup matches cannot be shown on iFollow – either domestically or abroad – and the game has not been selected for live television coverage.
There will be post-match reaction on the website and our official YouTube channel, with highlights to follow on Sunday.
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ALSO IN EMIRATES FA CUP
Games kick-off at 3pm unless stated
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Accrington v Barnet
AFC Wimbledon v Chesterfield
Barnsley v Crewe
Cambridge v Grimsby
Charlton v Stockport
Forest Green v Alvechurch
Hartlepool v Harrogate
Oxford v Exeter
Sheffield Wednesday v Mansfield
Shrewsbury v Peterborough
Walsall v Carlisle
Wrexham v Farnborough (3.15pm)
Dagenham & Redbridge v Gillingham (5pm)
Ebbsfleet v Fleetwood (12.30pm)
Bristol Rovers v Boreham Wood (2pm)
Burton v Chippenham (2pm)
Newport v Derby (3.15pm)
Ipswich v Buxton (5pm)