Pompey will look to maintain the division’s only unbeaten record when they visit Barnsley this evening (7.45pm kick-off).
In fact, their run of league games without losing now stands at 18 – comfortably better than any other top-flight or EFL side.
But the Blues will likely receive a stern test tonight against a team who sit one place above them in the standings.
The Tykes are in fifth spot thanks to their superior goal difference, which received a boost when they routed Port Vale 7-0 on the opening day.
Neill Collins is tasked with trying to mastermind promotion to the Championship, having replaced Swansea-bound Michael Duff in the Oakwell hotseat over the summer.
His predecessor guided Barnsley to the play-offs last season and they saw off Bolton over two legs to book a trip to Wembley.
There was heartache in the capital, however, as Josh Windass struck in stoppage-time at the end of extra-time to ensure it was Sheffield Wednesday who went up.
The Reds head into this fixture on the back of four successive wins in all competitions, while League One’s top scorer Devante Cole has already struck eight times.
Pompey were beaten on their most recent trip to Oakwell back in March, with Colby Bishop netting in a 3-1 defeat.
Josh Dockerill (knee), Tom Lowery (knee), Anthony Scully (knee) and Kusini Yengi (ankle) all remain sidelined.
Pompey hope to have Christian Saydee available following a minor hamstring problem, while Joe Morrell and Joe Rafferty both return from suspension.
Luca Connell (illness) and Robbie Cundy (hip) are both expected to miss out for Barnsley, but Callum Styles should have recovered from a sickness bug.
VIEW FROM THE DRESSING ROOM
Read the thoughts of head coach John Mousinho ahead of the game.
HEAD TO HEAD
Pompey: 22 wins
Barnsley: 19 wins
On the road
Pompey: 7 wins
Barnsley: 14 wins
Tickets can longer be purchased through Pompey, but are on sale at the away turnstiles at Oakwell this evening.
Click here for more information if you are attending the game.
Referee: Lewis Smith
Assistants: Callum Jones and Stephen Wade
Fourth Official: Daniel Middleton
Domestic iFollow subscribers can also enjoy audio commentary from Andrew Moon and Guy Whittingham as usual, but will need to purchase a match pass if they want to watch the game.
There will be post-match reaction on the website and our official YouTube channel, with highlights to follow on Wednesday.
ALSO IN LEAGUE ONE
Games kick-off at 7.45pm
Peterborough v Cheltenham
Port Vale v Burton