Championship opposition for Blues
It is the Blues who have the better overall record in meetings between the sides, with 21 victories compared to the Royals' 11.
But the sides have not met since they were both in the second tier during the 2011/12 campaign, when each club won their home fixture 1-0.
Pompey have already seen off Championship opposition, beating Derby 2-1 at home in the first round, while Reading advanced with an extra-time triumph at Colchester
Aston Villa v Notts County
Walsall v Brighton & Hove Albion
Crystal Palace v Shrewsbury Town
Sheffield Wednesday v Oxford United
POMPEY v Reading
Hartlepool United v AFC Bournemouth
Fulham v Sheffield United
Milton Keynes Dons v Cardiff City
Hull City v Rochdale
Sunderland v Exeter City
Bury v Leicester City
Doncaster Rovers v Ipswich Town
Rotherham United v Norwich City
Swansea City v York City
Queens Park Rangers v Carlisle United
Barnsley v Everton
Peterborough United v Charlton Athletic
Birmingham City v Gillingham
Newcastle United v Northampton Town
West Bromwich Albion v Port Vale
Wolverhampton Wanderers v Barnet
Burton Albion v Middlesbrough
Luton Town v Stoke City
Preston North End v Watford