All you need to know about League Two clash
Pompey are one of just five clubs in the top four divisions of English football who have yet to lose in the league this season.
And aiming to end that run this weekend will be an Oxford side managed by former Blues boss Michael Appleton.
Striker Ryan Taylor joined United after leaving Fratton Park at the end of last term, although has yet to score in nine appearances.
His new side currently sit eighth in the League Two table, having collected 12 points from their first seven games.
Oxford took just a single point off Pompey last season, playing out a goalless draw at Fratton Park after losing to a single goal at the Kassam Stadium.
Pompey will be without Gary Roberts, who injured his ankle in last week's victory over Barnet, while Jack Whatmough (knee) is still sidelined.
Kemar Roofe and Johnny Mullins could both feature for the hosts after returning to training, but Sam Long (ankle) is out.
HEAD TO HEAD
Pompey: 22 Wins
Oxford: 18 Wins
Pompey: 7 Wins
Oxford: 15 Wins
February 28 2015
Pompey PlayerHD subscribers can listen to live online commentary from the Kassam Stadium.
There will be post-match reaction on the website, Pompey PlayerHD and our official YouTube channel
, with extended highlights to follow on Sunday.
Pompey have sold their entire allocation of 2,500 tickets for this game and no more will be made available.
Oxford are 7/5
favourites to win the game with Sky Bet, with Pompey on offer at 15/8
Read our betting preview here
and remember to register at www.skybet.com/pompey
to earn money for the club whenever you have a flutter.
ALSO IN LEAGUE TWO
Accrington v Exeter
AFC Wimbledon v Notts County
Barnet v Stevenage
Crawley v Yeovil
Dag & Red v Newport
Hartlepool v Cambridge
Leyton Orient v Wycombe
Luton v Mansfield
Morecambe v Northampton
Plymouth v Bristol Rovers
York v Carlisle