All you need to know about League Two clash
Pompey’s hopes of achieving automatic promotion now look slim following successive defeats to Plymouth and York.
But the Blues could guarantee at least a play-off spot if they can see off Wycombe at Fratton Park this weekend.
Three points would mean that they can no longer be caught by Saturday’s opponents, who currently sit just outside the top seven.
Cambridge, Exeter and Leyton Orient would also need to drop points against Notts County, Bristol Rovers and AFC Wimbledon respectively.
But even if they all triumphed, they could only finish level on points with Pompey, who have a far superior goal difference.
Wycombe go into the game on the back of a five-match winless run, which includes three successive draws.
They have a tough end to the campaign, meeting promotion-chasing Accrington and Oxford in their final two fixtures.
But Gareth Ainsworth’s side have the best defensive record in the fourth tier, conceding just 38 goals all season – and a measly 15 on their travels.
Pompey drew 2-2 when they visited Adams Park back in November, with efforts from Caolan Lavery and Adam Webster helping them recover from a two-goal deficit.
Four of the previous six competitive meetings between the sides have ended all square and the Blues have never beaten the Chairboys at Fratton Park.
Conor Wilkinson is still sidelined with a groin problem, while Kyle Bennett and Adam Webster are both unlikely to feature after picking up ankle injuries at York.
There are also doubts over Christian Burgess (ankle), Ryan Fulton (thigh) and Gary Roberts (head).
Wycombe will be without Paris Cowan-Hall (Achilles), Matt Bloomfield (arm), Alex Lynch (thigh), Luke O’Nien (knee) and Sam Wood (knee).
But Joe Jacobson and Danny Rowe could feature for the visitors, with the duo both returning from injury lay-offs.
Read what Paul Cook has to say about the game or subscribe to Pompey PlayerHD for extended interviews with the manager and Marc McNulty.
HEAD TO HEAD
Pompey: 1 Win
Wycombe: 1 Win
At Fratton Park
Pompey: 0 Wins
Wycombe: 1 Win
Wycombe 2 (Harriman, Thompson)
Pompey 2 (Lavery, Webster)
November 28 2015
Pompey PlayerHD subscribers can listen to live online commentary from Fratton Park from 2pm on Saturday.
There will be post-match reaction on the website, Pompey PlayerHD and our official YouTube channel, with extended highlights to follow at midday on Sunday.
Local listeners can hear commentary on Express FM or BBC Radio Solent (not online), while The News will also have extensive coverage.
Tickets can be bought online here. On the day of the game they will be sold from the booths behind the Fratton End, which are open from 2pm.
Pompey are 4/5 favourites with Sky Bet to claim all three points, while the visitors can be backed at 18/5.
Click here to read our betting preview and remember to register at www.skybet.com/pompey to earn money for the club whenever you have a flutter.
ALSO IN LEAGUE TWO
Accrington v York
AFC Wimbledon v Leyton Orient
Bristol Rovers v Exeter
Crawley v Carlisle
Luton v Newport
Mansfield v Barnet
Morecambe v Stevenage
Notts County v Cambridge
Oxford v Hartlepool
Plymouth v Dag & Red
Yeovil v Northampton