All you need to know about League Two clash
Pompey fans will have fond memories of their last visit to Crewe back in 2013.
Guy Whittingham’s side won the League One encounter 2-1, courtesy of goals from Patrick Agyemang and David Connolly.
That ended a run of 23 successive games without a victory for a side destined to drop into the fourth tier.
The Railwaymen were relegated last season after finishing rock bottom of League One – 16 points adrift of safety.
But they got the current campaign off to an encouraging start with a 2-1 victory at Stevenage.
Steve Davis’ side followed that up with another away win on Tuesday night, this time coming from behind to knock Sheffield United out of the EFL Cup.
This will be the first meeting between the sides in the bottom tier since the 1979/80 campaign, when Pompey won promotion and Crewe had to seek re-election.
Pompey are likely to make plenty of changes from the side that exited the EFL Cup earlier in the week.
There are no new injury concerns, but the Blues are still without Matt Clarke (groin), Ben Close (hamstring) and Brandon Haunstrup (collarbone).
Billy Bingham (ankle) and Perry Ng (hip) are doubts for the hosts, while Callum Ainley has recovered from a groin strain.
Read what Paul Cook and Christian Burgess have to say about Saturday’s game or watch extended interviews on Pompey PlayerHD.
HEAD TO HEAD
Pompey: 6 Wins
Crewe: 6 Wins
Pompey: 2 wins
Crewe: 3 Wins
Tickets are on sale from Pompey until 4pm on Friday, but none will be available at Alexandra Stadium on the day of the game.
Pompey PlayerHD subscribers can listen to live commentary from Alexandra Stadium from 2pm on Saturday.
There will be post-match reaction on the website, Pompey PlayerHD and our official YouTube channel, with highlights to follow on Sunday.
Local listeners can hear commentary on Express FM or BBC Radio Solent, while The News will also have extensive coverage.
Pompey are evens favourites with Sky Bet to claim all three points, while the hosts can be backed at 14/5.
ALSO IN LEAGUE TWO
Barnet v Accrington
Carlisle v Plymouth
Colchester v Cambridge
Doncaster v Crawley
Exeter v Hartlepool
Leyton Orient v Newport
Luton v Yeovil
Mansfield v Cheltenham
Morecambe v Blackpool
Notts County v Stevenage
Wycombe v Grimsby