All you need to know about League Two clash
With Pompey looking to get their promotion challenge back on track, the omens are good for victory this weekend.
Cambridge have only won one of the 15 meetings between the sides – and that sole triumph came all the way back in 1978.
The Blues have come out on top in the last four encounters, which include a 6-2 rout at the Abbey Stadium last term.
Pompey will be keen to claim all three points after dropping out of the play-off places with defeat at Barnet during the week.
United, meanwhile, will leapfrog them in the League Two table if they are victorious on Saturday.
They currently sit in 11th spot, having won three of their last four games and lost just one of the last six.
Shaun Derry is in charge at the Abbey Stadium after replacing another ex-Blues player, Richard Money, in November.
Cambridge have won six times on their league travels this term, seeing off AFC Wimbledon (2-1), Yeovil (3-2), Morecambe (4-2), Plymouth (2-1), Dagenham (3-0) and Leyton Orient (3-1).
But the Fratton faithful will be hoping that their barren run on the south coast continues.
Gareth Evans (hamstring) and Gary Roberts (hamstring) are both doubts for Pompey, but Christian Burgess is available after serving a one-match ban.
Former Blues midfielder James Dunne will not feature because of a gentleman’s agreement between the sides.
Keith Keane has returned from a spell on loan at Stevenage, but Barry Corr (knee) and Conor Newton (back and hamstring) are both sidelined.
Read what Paul Cook and Ben Davies think about Saturday’s match or subscribe to Pompey PlayerHD for extended interviews with the manager and Danny Hollands.
HEAD TO HEAD
Pompey: 11 Wins
Cambridge: 1 Win
At Fratton Park
Pompey: 6 Wins
Cambridge: 0 Wins
Cambridge 1 (Simpson)
Pompey 3 (Legge (og), Tubbs 2)
October 10 2015
Pompey PlayerHD subscribers can listen to live online commentary from Fratton Park from 2pm on Saturday.
There will be post-match reaction on the website, Pompey PlayerHD and our official YouTube channel, with extended highlights to follow at midday on Sunday.
Local listeners can hear commentary on Express FM or BBC Radio Solent (not online), while The News will also have extensive coverage.
Tickets can be bought online here. On the day of the game, they are available from the booths behind the Fratton End, which open at 11am.
Pompey are 8/13 favourites with Sky Bet to collect all three points, while the visitors can be backed at 9/2.
Click here to read our betting preview and remember to register at www.skybet.com/pompey to earn money for the club whenever you have a flutter.
ALSO IN LEAGUE TWO
Accrington v Barnet
AFC Wimbledon v Oxford
Dag & Red v Yeovil
Hartlepool v Northampton
Leyton Orient v Crawley
Morecambe v Carlisle
Newport v Mansfield
Plymouth v Notts County
Stevenage v Exeter
Wycombe v Bristol Rovers
York v Luton