All you need to know about League Two clash
Pompey suffered a gut-wrenching blow in the final seconds of their game at Morecambe on Tuesday night.
So the players will be pleased to quickly have the chance to get that 94th-minute equaliser from a goalkeeper out of their system.
They only faced Leyton Orient at the Matchroom Stadium on Boxing Day and that festive clash was certainly an eventful affair.
The Blues were leading through Connor Essam’s early own-goal and appeared to be cruising to victory in the capital.
But then Adam Webster was sent off, League Two top scorer Jay Simpson scored the resulting penalty and Ollie Palmer gave the hosts an advantage before the break.
Orient went 3-1 up before they too had a man sent off and Gareth Evans’ strike proved no more than a consolation.
It has been a hectic period for the Londoners since then, with Ian Hendon being dismissed as manager and replaced by Kevin Nolan.
The former Bolton, Newcastle and West Ham star has not hung up his boots, however, and brought himself off the bench in each of their past two matches.
Pompey have not beaten Orient at Fratton Park since a 2-0 League Cup triumph in August 1996.
They were infamously beaten 4-1 in an FA Cup third round tie in 2002 and then lost 3-2 in a League One encounter 10 years later.
Danny Hollands (leg) is still sidelined and Adam Webster (hamstring) is a doubt, while recent loan signings Kieron Freeman and Michael Smith could make their Fratton bows.
Former Pompey loanee Paul McCallum and midfielder Dean Cox are both missing for the visitors with knee ligament injuries.
Nolan could hand debuts to deadline day loan arrivals Nicky Hunt and Jerome Binnom-Williams, although Cole Kpekawa has returned to QPR.
Read what Paul Cook and Marc McNulty have to say about the match or subscribe to Pompey PlayerHD for extended interviews with the manager and Gareth Evans.
HEAD TO HEAD
Pompey: 15 Wins
Leyton Orient: 12 Wins
At Fratton Park
Pompey: 9 Wins
Leyton Orient: 4 Wins
Leyton Orient 3 (Palmer 2, Simpson)
Pompey 2 (Essam (og), Evans)
December 26 2015
Pompey PlayerHD subscribers can listen to live online commentary from Fratton Park from 2pm on Saturday.
There will be post-match reaction on the website, Pompey PlayerHD and our official YouTube channel, with extended highlights to follow at midday on Sunday.
Local listeners can hear commentary on Express FM or BBC Radio Solent (not online), while The News will also have extensive coverage.
Tickets can be bought online here. On the day of the game they will be available from the booths behind the Fratton End, which are open from 11am.
Pompey are evens favourites with Sky Bet to claim all three points, while the visitors can be backed at 11/4.
Click here to read our betting preview and remember to register at www.skybet.com/pompey to earn money for the club whenever you have a flutter.
ALSO IN LEAGUE TWO
Bristol Rovers v AFC Wimbledon
Cambridge v Dag & Red
Carlisle v Accrington
Exeter v Oxford
Mansfield v Morecambe
Newport v Barnet
Northampton v York
Notts County v Hartlepool
Stevenage v Crawley
Wycombe v Luton
Yeovil v Plymouth