Everything you need to know about League Two clash
Both sides will be desperate for points when Pompey visit Huish Park on Saturday – but for very different reasons.
The visitors are looking to remain in the top seven and keep their automatic promotion challenge on track.
Yeovil, meanwhile, want to climb out of the bottom two, having fallen into the relegation places without even playing during the week.
They were beaten by fellow strugglers Hartlepool last Saturday and were then leap-frogged by York three days later.
Dropping out of the Football League would complete a remarkable slide for the Glovers, who were playing in the Championship two years ago.
Former Yeovil midfielder Darren Way is the man tasked with trying to prevent a third successive relegation.
He took charge in December after the club decided to part company with Paul Sturrock following 12 league matches without a win.
The Glovers have gained maximum points on their own patch just three times this season, with Luton, York and Crawley leaving empty-handed.
But they did manage to grab a point in a dull goalless encounter at Fratton Park earlier in the campaign.
Danny Hollands has returned to training after recovering from a fractured leg, but is not ready to feature against Yeovil, while Conor Chaplin is out with an ankle problem.
Former Blues midfielders Jack Compton and Wes Fogden are both sidelined for the Glovers, with Kevin Dawson, Jordan Gibbons and Omar Sowunmi also injured and Nathan Smith suspended.
However, eight-goal top scorer Ryan Bird is set to feature against the club where he netted three times in 25 appearances.
Read what Paul Cook and Michael Doyle have to say about the match or subscribe to Pompey PlayerHD for extended interviews with the manager and Enda Stevens.
HEAD TO HEAD
Pompey: 2 Wins
Yeovil: 1 Win
At Huish Park
Pompey: 2 Wins
Yeovil: 0 Wins
October 3 2015
Pompey PlayerHD subscribers can listen to live online commentary from Huish Park from 2pm on Saturday.
There will be post-match reaction on the website, Pompey PlayerHD and our official YouTube channel, with extended highlights to follow at midday on Sunday.
Local listeners can hear commentary on Express FM or BBC Radio Solent (not online), while The News will also have extensive coverage.
Pompey have sold their full allocation of tickets and no more will be made available.
Pompey are 8/11 favourites with Sky Bet to claim all three points, while the hosts can be backed at 18/5.
Click here to read our betting preview and remember to register at www.skybet.com/pompey to earn money for the club whenever you have a flutter.
ALSO IN LEAGUE TWO
Exeter v Newport (1pm)
Barnet v AFC Wimbledon
Bristol Rovers v Morecambe
Cambridge v York
Carlisle v Stevenage
Crawley v Plymouth
Luton v Hartlepool
Mansfield v Dag & Red
Northampton v Wycombe
Notts County v Leyton Orient
Oxford v Accrington