All you need to know about League Two clash
Pompey fans will not have fond memories of their last visit to Home Park just five months ago.
There was plenty of confidence going into the second leg of a play-off clash with Plymouth that was locked at 2-2.
Paul Cook’s side were perhaps unfortunate not to hold an advantage following a breathless Fratton encounter, while Jamille Matt was arguably fortunate to escape a ban for a headbutt on Michael Doyle.
But it proved to be one game too far for the injury-ravaged Blues, who cruelly conceded in the final minute in Devon.
Plymouth then suffered their own heartache 15 days later, losing 2-0 to AFC Wimbledon at Wembley to miss out on promotion.
Now both sides are trying to put that disappointment behind them and launch another push for promotion this season.
The Pilgrims have certainly made a bright start, sitting on top of the pile after 12 games – five points clear of their nearest challengers and eight ahead of fourth-placed Pompey.
They lost their opening two games against Luton and Carlisle, but are now on a 10-match unbeaten run that has included nine victories.
Adam Buxton (ankle) and Drew Talbot (hamstring) are both sidelined, while Noel Hunt (groin) remains a doubt.
Former Pompey duo Sonny Bradley and Jake Jervis are expected to feature for the hosts.
But Plymouth are without Ryan Brunt (knee), Paul-Arnold Garita (hamstring), Gary Sawyer (stomach) and Oscar Threlkeld (knee).
Read what Paul Cook and Michael Doyle have to say about the game or watch pre-match video content on Pompey PlayerHD.
HEAD TO HEAD
Pompey: 26 Wins
Plymouth: 24 Wins
At Home Park
Pompey: 10 Wins
Plymouth: 14 Wins
Pompey have sold their full allocation of tickets and no more will be available to buy at Home Park.
Pompey PlayerHD subscribers can listen to live commentary from Home Park from 2pm on Saturday.
There will be post-match reaction on the website, Pompey PlayerHD and our official YouTube channel, with highlights to follow on Sunday.
Local listeners can hear commentary on Express FM or BBC Radio Solent, while The News will also have extensive coverage.
Pompey are 5/4 favourites with Sky Bet to secure all three points, while the hosts can be backed at 11/5.
Click here to read our full betting preview and sign-up to www.skybet.com/pompey for great offers.
ALSO IN LEAGUE TWO
Accrington v Blackpool
Barnet v Exeter
Cambridge v Grimsby
Carlisle v Hartlepool
Cheltenham v Crawley
Doncaster v Colchester
Leyton Orient v Luton
Mansfield v Wycombe
Morecambe v Stevenage
Notts County v Crewe
Yeovil v Newport
LAST SEASON’S HOME PARK WIN