Pompey will have to overcome the odds if they are to leave Wigan with any points this weekend.
It is the hosts – who are, of course, managed by former Fratton boss Paul Cook – that are the 19/20 favourites all three points.
The Blues can be backed at 3/1 with Sky Bet to secure victory at the DW Stadium, with the draw at 12/5.
It was goalless when the sides last met in the north-west in 2010 and a repeat of that scenario is priced at 17/2.
But the more optimistic punters among you might instead prefer to take a look at 9/1 for a 1-0 win or 12/1 for a 2-1 triumph.
You can also find odds of 15/2 on Pompey being level at the interval before going on to emerge victorious.
Brett Pitman has bagged all of the Blues’ league goals so far and is the 13/2 favourite to net the opener on Saturday.
Elsewhere in the first scorer market, Conor Chaplin, Jamal Lowe and Jack Whatmough are available at 7/1, 17/2 and 50/1 respectively.
Please gamble responsibly and remember that odds are subject to change.
Sign-up to a Sky Bet account now at www.skybet.com/pompey for more odds and some great offers.