Pompey will go searching for a fourth successive victory when they make the midweek trip to Peterborough.
But it is the hosts – currently one place below their opponents in 11th – who are narrow 6/4 favourites with Sky Bet to triumph.
Kenny Jackett’s side can be backed at 17/10 to take all three points back to the south coast, with the draw at 5/2.
The Blues were 3-0 victors on their last trip to London Road in January 2012 and a repeat of that scenario is available at 28/1.
Those expecting a tighter encounter, however, might be tempted by 9/1 for either a 1-0 or 2-1 victory.
Brett Pitman is the 4/1 favourite to continue his prolific spell by netting the opener or 13/2 to bag a brace.
Elsewhere in the first goalscorer market, Conor Chaplin, Jamal Lowe and Christian Burgess are on offer at 13/2, 10/1 and 40/1 respectively.
Please gamble responsibly and remember that odds are subject to change.
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