Stuart O’Keefe and Oliver Hawkins go straight into the Pompey side to face Rotherham this afternoon.
A fit-again Matt Clarke also returns after recovering from the groin injury that has kept him sidelined since pre-season.
Conor Chaplin is also rewarded for his leveller at Wigan, as Kenny Jackett makes four changes and switches to a 3-4-1-2 system.
Gareth Evans misses out through suspension, while Danny Rose, Dion Donohue and Kyle Bennett also make way.
Pompey: McGee; Whatmough, Burgess, Clarke; Lowe, O’Keefe, May, Haunstrup; Pitman (c); Chaplin, Hawkins
Subs: Bass, Thompson, McCrory, Close, Donohue, Kennedy, Naismith