Kenny Jackett hands competitive debuts to four of his summer signings.
Craig MacGillivray, Lee Brown, Tom Naylor and Ronan Curtis are all thrown straight into the side to face Luton on the opening day of the 2018/19 campaign.
There is also a surprise start for Jamal Lowe, who was expected to miss out with an ankle problem.
And Dion Donohue has recovered enough from illness to take his place on the bench.
Pompey: MacGillivray; Thompson, Whatmough, Clarke, Brown; Lowe, Walkes, Naylor, Haunstrup; Pitman (c), Curtis
Subs: McGee, Burgess, Donohue, Close, Evans, Chaplin, Hawkins