The road to Wembley was ended – at least in the Carabao Cup – by AFC Wimbledon during the week.
But the Blues will look to put that behind them and continue their encouraging start to the 2018/19 League One campaign.
Kenny Jackett’s side will try to make it three successive victories by seeing off Oxford at Fratton Park this weekend.
It has been the reverse for their opponents, who recovered from back-to-back league defeats to beat Coventry in the cup.
Those losses against Barnsley (0-4) and Fleetwood (0-2) mean they currently prop up the division, albeit at a very early stage.
United are looking to improve on last season’s 16th-placed finish, with just a six-point buffer between them and the drop zone.
Karl Robinson has taken advantage of his first pre-season at the helm by making a host of signings, including the loan capture of ex-Pompey winger Ricky Holmes.
His maiden game as head coach was at Fratton Park back in March and it ended in defeat, courtesy of Kal Naismith’s goal and a Brett Pitman brace.
Pompey are still without the injured pair of Dion Donohue (groin) and Nathan Thompson (knee), but new loan midfielder Ben Thompson could make his debut.
Former Blues keeper Simon Eastwood (finger) and Samir Carruthers (knee) miss out for the visitors, while Holmes (back) is also a doubt.
HEAD TO HEAD
Pompey: 24 wins
Oxford: 21 wins
At Fratton Park
Pompey: 16 wins
Oxford: 4 wins
Seats can be secured online here or from the ticket office in Anson Road.
Subject to availability, they will be sold from both ticket offices from 9am on Saturday, while collections can be made from main reception.
Overseas subscribers and match pass holders can watch the action – now with on-screen graphics – and commentary will begin from around 10 minutes before kick-off.
ALSO IN LEAGUE ONE
Accrington v Charlton
Barnsley v AFC Wimbledon
Burton v Doncaster
Coventry v Plymouth
Fleetwood v Rochdale
Peterborough v Luton
Shrewsbury v Blackpool
Southend v Bradford
Walsall v Gillingham
Wycombe v Bristol Rovers
Sunderland v Scunthorpe