Pompey and Plymouth have been engaged in some pivotal meetings in recent seasons.
It was Argyle who came out on top when they clashed in the play-offs in 2016, while the Blues edged the race for the League Two title the following year.
And both clubs ultimately came up just short in the battle to stake a place in the third tier’s top six last term.
The Pilgrims do not currently look like a side who will challenge for promotion, but showed last campaign that you write them off at your peril.
Derek Adams’ men were rock bottom following a 1-0 defeat at Fratton Park in late November, only to then go on an incredible run that saw just one loss from 17 games.
They have yet to win in the league so far this season, with three defeats and two draws from their five fixtures.
Plymouth were thrashed 5-1 on home soil by high-flying Peterborough in the latest of those and a 3-2 Carabao Cup reverse at Millwall followed four days later.
Four of the past six meetings between the sides have ended all square – while the other two were won by a single goal – so perhaps a close contest should be expected on Saturday.
Pompey are without Dion Donohue, as he continues to build fitness following a groin problem, but loan signing Andre Green could make his debut.
Stuart O’Keefe is set to make his first league appearance for Argyle against his former club, but their manager Derek Adams is serving a touchline ban.
HEAD TO HEAD
Pompey: 27 wins
Plymouth: 24 wins
At Fratton Park
Pompey: 17 wins
Plymouth: 10 wins
There are now only limited tickets available in the Milton End – click here to secure your seat while they are still available.
Overseas subscribers and match pass holders can watch the action – now with on-screen graphics – and commentary will begin from around 10 minutes before kick-off.
ALSO IN LEAGUE ONE
Accrington v Scunthorpe
Barnsley v Gillingham
Burton v AFC Wimbledon
Coventry v Rochdale
Fleetwood v Bradford
Peterborough v Doncaster
Shrewsbury v Bristol Rovers
Southend v Charlton
Sunderland v Oxford
Walsall v Blackpool
Wycombe v Luton
LAST FRATTON MEETING