Pompey and Plymouth have been engaged in some pivotal meetings in recent seasons.
It was Argyle who came out on top when they clashed in the play-offs in 2016, while the Blues edged the race for the League Two title the following year.
And both clubs ultimately came up just short in the battle to stake a place in the third tier’s top six last term.
The Pilgrims do not currently look like a side who will challenge for promotion, but showed last campaign that you write them off at your peril.
Derek Adams’ men were rock bottom following a 1-0 defeat at Fratton Park in late November, only to then go on an incredible run that saw just one loss from 17 games.
They have yet to win in the league so far this season, with three defeats and two draws from their five fixtures.
Plymouth were thrashed 5-1 on home soil by high-flying Peterborough in the latest of those and a 3-2 Carabao Cup reverse at Millwall followed four days later.
Four of the past six meetings between the sides have ended all square – while the other two were won by a single goal – so perhaps a close contest should be expected on Saturday.
TEAM NEWS
Pompey are without Dion Donohue, as he continues to build fitness following a groin problem, but loan signing Andre Green could make his debut.
Stuart O’Keefe is set to make his first league appearance for Argyle against his former club, but their manager Derek Adams is serving a touchline ban.
VIEW FROM THE DRESSING ROOM
Read the thoughts of Kenny Jackett and Matt Clarke or register for a free iFollow account to watch the below videos.
HEAD TO HEAD
Overall
Pompey: 27 wins
Plymouth: 24 wins
13 draws
At Fratton Park
Pompey: 17 wins
Plymouth: 10 wins
5 draws
TICKETS
There are now only limited tickets available in the Milton End – click here to secure your seat while they are still available.
MATCH COVERAGE
Domestic iFollow subscribers can listen to live commentary from Andy Moon and Guy Whittingham by signing into their account and visiting the match centre from 2pm on Saturday.
Overseas subscribers and match pass holders can watch the action – now with on-screen graphics – and commentary will begin from around 10 minutes before kick-off.
Click here for more information about using iFollow on a matchday and click here for information on downloading the app, so you can access content on your mobile device.
We will have updates throughout the game on Twitter and the match centre. You can also see behind-the-scenes content on our Instagram story and Snapchat account.
There will be post-match reaction on the website, iFollow and our official YouTube channel, with highlights to follow on Sunday.
Local listeners can hear commentary by tuning in to either Express FM or BBC Radio Solent.
BETTING
Pompey are the 3/4 favourites with Sky Bet to secure all three points, while the visitors can be backed at 18/5.
Click here to read our full betting guide and visit www.skybet.com/pompey to earn money for the club when you place a bet. Please gamble responsibly.
ALSO IN LEAGUE ONE
Accrington v Scunthorpe
Barnsley v Gillingham
Burton v AFC Wimbledon
Coventry v Rochdale
Fleetwood v Bradford
Peterborough v Doncaster
Shrewsbury v Bristol Rovers
Southend v Charlton
Sunderland v Oxford
Walsall v Blackpool
Wycombe v Luton
LAST FRATTON MEETING