Pompey have a good recent record against Luton, having not lost in any of the past seven league meetings.
They won five of those encounters – including both games on the way to securing the 2016/17 fourth tier title.
But the Hatters did narrowly triumph in the first round of the FA Cup last term and went on to face Premier League outfit Newcastle.
Luton were favourites to win League Two at the start of last season, but were pipped to top spot by unfancied Accrington.
They achieved their ultimate aim of promotion, however, and will play in the third tier for the first time since 2008.
The Hatters were comfortably the division’s top scorers, with 8-2, 7-1 and 7-0 victories contributing towards a tally of 94 goals.
Nathan Jones led Luton to the play-offs in his first full season in charge at Kenilworth Road, before securing automatic promotion a year later.
He had a spell with the Hatters early in his playing career, but left without making a first team appearance.
Jones then had spells in Spain and also turned out for Southend, Brighton and Yeovil, starting his coaching career with the latter.
Sonny Bradley – who made 39 appearances during a single season at Fratton Park – has recently joined Luton from Plymouth.
Fellow defender Dan Potts had a brief spell on loan with the Blues from West Ham in 2013, playing six times.
HEAD TO HEAD
Pompey: 16 wins
Luton: 22 wins
Last Fratton meeting
Pompey 1 (Burgess)
January 2 2017
Last away meeting
Luton 1 (Collins)
FA Cup R1
November 4 2017
Best league finish: 7th in Division One (1986/87)
Nickname: The Hatters
Distance from Fratton Park: 97.3 miles
Estimated drive time: 1 hour 48 minutes
2018/19 title odds: 12/1
2017/18 League Two: 2nd
2016/17 League Two: 4th
2015/16 League Two: 11th
2014/15 League Two: 8th
2013/14 National League: 1st
2012/13 National League: 7th
2011/12 National League: 5th
2010/11 National League: 3rd
2009/10 National League: 2nd
2008/09 League Two: 24th