A battling Pompey Women performance proved in vain as they lost 3-0 to Plymouth at the PMC Stadium.
Jay Sadler made several changes to the side that routed Poole in the cup the previous week, including a return for Robyn Levett between the sticks.
The visitors came into the contest in good form, having won four of their opening five National League South games.
And they broke the deadlock after just 15 minutes when the Blues were caught in possession following a pass out from the back.
Jessie Jones stole the ball from Danielle Rowe and her rising effort managed to beat Levett and fly into the net.
The hosts did grow into the encounter despite that early setback, with Rachel Panting and Daisy McLachlan both having opportunities to level.
Instead it was Argyle who were celebrating again before the break, as the lively Zoe Cunningham crossed for Kayley Lane to guide a header home at the far post.
Half Time: Pompey 0 Plymouth 2
Pompey were quickly out of the blocks following the restart and came close to reducing the deficit when Panting held the ball up well in the box.
She was then able to feed the onrushing Carla Perkins, whose shot with the outside of the boot was saved by Lindsay Rogers.
It was a familiar tale of Panting and McLachlan looking more likely to hit the target for the Blues, although as the half progressed, it was clear it was not going to be their day.
Meanwhile, Plymouth were creating openings of their own and managed to wrap the points up in the closing stages.
Cunningham was the provider once more, with Jones doubling her tally for the afternoon with a powerful header.
Pompey kept fighting in search of a consolation goal, but their Devon opponents were able to protect a clean sheet.
Pompey: Levett; Kirby, Tonks, Southgate (c), Currie; Geer, James, Rowe, Perkins (May 67); McLachlan, Panting
Subs not used: Younger, Bradley, Anu