Pompey will look to stay in the automatic promotion race by beating Peterborough on home soil on Tuesday evening.
And Kenny Jackett’s are the 4/6 favourites with Sky Bet to secure the three points they need at Fratton Park.
The visitors – who are chasing the final League One play-off position – can be backed at 18/5, with the draw at 14/5.
It finished 2-1 when the sides met in the reverse fixture earlier in the campaign and a repeat of that scenario carries odds of 15/2.
A 1-0 scoreline – which is what happened when Jackett's men progressed in January’s Checkatrade Trophy tie – is also on offer at 15/2.
More optimistic punters might even be attracted by 12/1 for a 3-0 triumph or 50/1 for a free-scoring 4-2 success.
You can also take advantage of a Sky Bet boost, with the Blues coming out on top in a contest where both teams find the target moving from 21/10 to 11/4.
Those anticipating a tough evening should take a look at Pompey recovering from an interval deficit to take the points at 25/1.
Ronan Curtis and Jamal Lowe are the joint 7/2 favourites to net the opener, ahead of Oli Hawkins and Brett Pitman at 9/2.
Elsewhere in the first goalscorer market, Gareth Evans, Tom Naylor and Lee Brown are available at 13/2, 12/1 and 50/1 respectively.
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