Pompey have to put derby thoughts to the back of their minds and focus on trying to find some consistency in the league.
They now travel to face a Blackpool outfit who have yet to taste defeat in the third tier so far this season.
Simon Grayson’s men have won three games and drawn twice, ensuring they are among a clutch of five sides on 11 points at the top of the table.
That includes home victories over Bristol Rovers and Oxford, meaning the Blues will be looking to become the first club to leave Bloomfield Road with all three points.
Their only loss came against Macclesfield in the Carabao Cup – and even then they were only seen off on penalties.
Pompey have won on each of their past two visits to Blackpool turf, with Ronan Curtis netting twice in a 2-1 triumph last term.
But there should be more people inside the stadium this time around, with Seasiders fans ending their boycott following the welcome removal of the Oyston family from the boardroom.
Their side have finished mid-table in each of the two campaigns since being promoted back to League One – and will now be looking to secure Championship football for the first time since 2015.
James Bolton (ankle), Oli Hawkins (foot) and Ryan Williams (quad) are all back in training, but none are likely to feature on Saturday.
Bryn Morris (groin) and Jack Whatmough (knee) are the only other first team players currently sidelined.
Blackpool do not have many fitness concerns, although there are doubts over Nathan Delfouneso (hamstring) and Matty Virtue (thigh).
HEAD TO HEAD
Pompey: 22 wins
Blackpool: 27 wins
At Bloomfield Road
Pompey: 7 wins
Blackpool: 16 wins
Pompey fans can buy tickets from the cash turnstiles at Blackpool on Saturday. Click here for more details.
Referee: Christopher Sarginson
Assistants: Chris Isherwood and Richard Woodward
Fourth Official: Wade Smith
Overseas subscribers and match pass holders can watch the action and commentary will begin from around 10 minutes before kick-off.
ALSO IN LEAGUE ONE
All games kick-off at 3pm
Accrington v MK Dons
AFC Wimbledon v Wycombe
Burton v Bristol Rovers
Gillingham v Bolton
Ipswich v Shrewsbury
Lincoln v Fleetwood
Oxford v Coventry
Peterborough v Sunderland
Rotherham v Tranmere
Southend v Rochdale