Pompey will look to put their first League One points on the board when they host Tranmere on Saturday.
Both sides were left disappointed on the opening day of the season, falling to defeats against Shrewsbury and Rochdale respectively.
Rovers found themselves three goals down on home soil, but netted twice in the closing stages to restore some pride.
However, the Merseysiders have enjoyed a remarkable rise under the guidance of Micky Mellon in the past couple of years.
He led them to National League promotion with a play-off victory over Boreham Wood in 2018 – just 12 months after they had lost to Forest Green at Wembley.
And Tranmere were back at the national stadium last term, dramatically beating Newport at the end of extra-time to seal a spot in the third tier.
They have been busy in the transfer market over the summer, with Chelsea loanee Jacob Maddox yesterday becoming the 11th new arrival.
It was an entertaining contest when the sides last met at Fratton Park for a League Two contest in February 2015.
Rovers roared into a 2-0 lead, but Craig Westcarr reduced Pompey’s deficit before a late Ryan Taylor brace secured victory.
James Bolton (ankle) is still doubtful for Pompey, while Bryn Morris (groin), Jack Whatmough (knee) and Ryan Williams (quad) are definitely out.
Ross McCrorie is available again after serving a one-match ban, while John Marquis is in contention after missing the last game when his partner went into labour.
Jake Caprice (ankle), Mark Ellis (knee), Evan Gumbs (knee) and Ishmael Miller (hamstring) are all sidelined for the visitors, with Rushian Hepburn-Murphy suspended.
HEAD TO HEAD
Pompey: 13 wins
Tranmere: 14 wins
At Fratton Park
Pompey: 7 wins
Tranmere: 7 wins
Seats are still available in the Milton End and can be bought online here or by visiting the Anson Road ticket office.
Subject to availability, tickets can be bought on the day of the game (with an increase in prices) from both ticket offices, which open at 9am.
Referee: Scott Oldham
Assistants: Christopher Kidd and Simon Shaw
Fourth Official: Dan Bonneywell
Overseas subscribers and match pass holders can watch the action and commentary will begin from around 10 minutes before kick-off.
ALSO IN LEAGUE ONE
All matches kick-off at 3pm
Bolton v Coventry
Bristol Rovers v Wycombe
Fleetwood v AFC Wimbledon
Gillingham v Burton
Ipswich v Sunderland
MK Dons v Shrewsbury
Oxford v Peterborough
Rochdale v Doncaster
Rotherham v Lincoln
Southend v Blackpool