Having progressed in the FA Cup on Saturday, Pompey will now try do the same in the Leasing.com Trophy against Northampton.
And Kenny Jackett’s side are the 4/11 favourites with Sky Bet to book their place in the third round inside 90 minutes at Fratton Park.
The visitors from League Two – who finished runners-up in Southern Group H – can be backed at 11/2.
Pompey emerged 3-1 winners when the sides last met back in December 2017, with a repeat of that scoreline carrying odds of 9/1.
Those anticipating a trickier evening could be interested in the 18/1 on offer for the Blues recovering from an interval deficit before coming out on top.
Forwards Ellis Harrison, John Marquis and Brett Pitman are the joint 9/2 favourites to net the opener.
And those who think the holders will once again be lifting the trophy at Wembley should note they are currently the 8/1 favourites.
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Please note that in-stadia betting is no longer available at Fratton Park.