Having progressed in the FA Cup on Saturday, Pompey will now try do the same in the Leasing.com Trophy against Northampton.
And Kenny Jackett’s side are the 4/11 favourites with Sky Bet to book their place in the third round inside 90 minutes at Fratton Park.
The visitors from League Two – who finished runners-up in Southern Group H – can be backed at 11/2.
Pompey emerged 3-1 winners when the sides last met back in December 2017, with a repeat of that scoreline carrying odds of 9/1.
Punters might instead be tempted to put their money on a narrower 1-0 success at 11/2 or even a 4-0 triumph at 14/1.
Those anticipating a trickier evening could be interested in the 18/1 on offer for the Blues recovering from an interval deficit before coming out on top.
Alternatively, you could have them leading at the break and full-time at 21/20 or winning without conceding at 6/5.
Forwards Ellis Harrison, John Marquis and Brett Pitman are the joint 9/2 favourites to net the opener.
Elsewhere in the first goalscorer market, Marcus Harness, Gareth Evans and Paul Downing are available at 6/1, 15/2 and 50/1 respectively.
And those who think the holders will once again be lifting the trophy at Wembley should note they are currently the 8/1 favourites.
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Please note that in-stadia betting is no longer available at Fratton Park.