Pompey’s unbeaten home record will face another stern test when they face Wycombe on Boxing Day.
But Kenny Jackett’s side are the 5/6 favourites with Sky Bet to secure another three-point haul at Fratton Park.
The visitors – who sit seven points clear at the top of League One – can be backed at 16/5, with the draw at 12/5.
It finished 2-2 when the sides met on the south coast last season and you can find odds of 14/1 on a repeat of that scoreline.
More optimistic punters, however, might prefer to put their money on a 1-0 victory at 6/1 or even a 4-0 success at 33/1.
And you can also take advantage of a Sky Bet boost, with the Blues coming out on top in a contest where both sides find the target moving from 11/4 to 10/3.
The hosts kept a clean sheet when beating Ipswich on Saturday, so winning without conceding again might prove tempting at 2/1.
Alternatively, those expecting a trickier contest should take a look at Pompey battling from behind to take the points at 11/1.
The forward trio of Ellis Harrison, John Marquis and Brett Pitman are the joint 9/2 favourites to net the opener.
Elsewhere in the first goalscorer market, top scorer Ronan Curtis, Ryan Williams and Christian Burgess are available at 6/1, 17/2 and 33/1 respectively.
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Please note that in-stadia betting is no longer available at Fratton Park.