Pompey are on the road for the final time before Christmas, with Accrington the destination for their latest League One fixture.
Kenny Jackett’s men are looking to extend a 10-match unbeaten run, while also returning to winning ways following last Saturday’s stalemate with Peterborough.
Their next opponents are down in 18th position, although do sit five points above the relegation places.
Stanley have enjoyed more success on their own patch this term – three of their four league victories have come at the Crown Ground.
And the most recent of them was certainly achieved in some style, with 10-man Bolton thrashed 7-1 three weeks ago.
John Coleman’s men also beat the same opposition on home soil a few days ago, this time to progress in the Leasing.com Trophy.
A big success story for the Reds has been the form of Colby Bishop, who gave up a teaching career to sign for the club over the summer and has already scored 10 goals.
Both of last season’s meetings finished all square at 1-1, with Oli Hawkins on target at the Crown Ground after Craig MacGillivray had saved a penalty.
Brandon Haunstrup requires an operation on his meniscus after limping off in the last game and is set to be out for six-eight weeks.
Pompey will also be without Christian Burgess, who has collected five bookings and serves a one-match ban.
Andy Cannon and Sean Raggett are both available after shaking off slight knocks, but Bryn Morris (groin) is injured and Jack Whatmough not ready for selection.
Accrington are close to having a full-strength squad to choose from, with Sean McConville (shoulder) the only doubt.
HEAD TO HEAD
Pompey: 6 wins
Accrington: 2 wins
Pompey: 2 wins
Accrington: 1 win
Pompey fans can secure seats online here or by visiting the Anson Road ticket office until 4pm today.
Tickets can also be bought at Accrington on the day of the game. Click here for full details.
Referee: Martin Coy
Assistants: Paul Newhouse and Chris Isherwood
Fourth Official: David Benton
Overseas subscribers and match pass holders can watch the action and commentary will begin from around 10 minutes before kick-off.
ALSO IN LEAGUE ONE
All games kick-off at 3pm
AFC Wimbledon v Doncaster
Fleetwood v Gillingham
Ipswich v Bristol Rovers
Lincoln v Tranmere
MK Dons v Oxford
Peterborough v Bolton
Shrewsbury v Coventry
Southend v Roterham
Sunderland v Blackpool
Wycombe v Burton