Pompey’s unbeaten home record in League One will certainly be put to the test over the Christmas period.
Leaders Wycombe visit the south coast on Boxing Day after second-placed Ipswich make the trip this weekend.
The Tractor Boys are aiming to bounce back to the Championship at the first attempt after finishing bottom last season.
And Paul Lambert’s men made an excellent start to the current campaign, only to see their form tail off in recent weeks.
They have failed to win any of their past four league fixtures – which included a goalless stalemate with the Chairboys – and also exited the FA Cup following a replay defeat to Coventry.
The East Anglian outfit have at least progressed to the third round of the Leasing.com Trophy, seeing off Peterborough on penalties.
Ipswich do have an impressive record on the road, with seven of their 10 three-point hauls coming away from Portman Road.
The sides have not met since an FA Cup third round clash during the 2015/16 campaign, with Pompey upsetting their higher-ranked opponents in a Fratton Park replay.
Lee Brown (Achilles) and Brandon Haunstrup (meniscus) are both missing after requiring operations on their injuries.
Christian Burgess is available again following a one-match ban, while Oli Hawkins could return having missed the last game following the birth of his son.
Bryn Morris (groin) is the only other player currently in the treatment room, while Jack Whatmough is not yet ready for selection.
Ipswich will be without Danny Rowe (knee) and Freddie Sears (knee), but Luke Chambers (neck) could be back.
HEAD TO HEAD
Pompey: 12 wins
Ipswich: 19 wins
At Fratton Park
Pompey: 4 wins
Ipswich: 10 wins
Fratton Park is full to capacity for Saturday’s game, but fans can check the eticketing site to see if any seats become available via the ticket exchange.
Referee: Brett Huxtable
Assistants: Garry Maskell and Bhupinder Gill
Fourth Official: Gary Parsons
Overseas subscribers and match pass holders can watch the action and commentary will begin from around 10 minutes before kick-off.
ALSO IN LEAGUE ONE
Games kick-off at 3pm unless otherwise stated
Gillingham v MK Dons (1pm)
Blackpool v Shrewsbury
Bolton v Southend
Bristol Rovers v Peterborough
Burton v Rochdale
Coventry v Lincoln
Doncaster v Accrington
Oxford v Wycombe
Rotherham v Fleetwood
Tranmere v AFC Wimbledon