Pompey switch their focus from one cup competition to another when they host Northampton in the Leasing.com Trophy tonight.
The competition holders eased through to the knockout stages with a game to spare, eventually taking top spot and guaranteeing a home tie.
Their opponents – who have never lifted the silverware – were runners-up behind Peterborough in Southern Group H.
A bonus-point draw with Arsenal was followed by a home defeat to Posh and a narrow victory at Cambridge.
The bigger priority for Keith Curle’s men, however, will be trying keep up their challenge for League Two promotion.
They are currently sitting in sixth position and are just three points outside the top three with more than half the season still to play.
The Cobblers – who relegated from the third tier at the end of the 2017/18 campaign – are unbeaten in eight games in all competitions and knocked Notts County out of the FA Cup at the weekend.
But their last visit to Fratton Park in December 2017 ended in a 3-1 defeat and they also lost on the south coast in an EFL Trophy tie that season.
Ross McCrorie, Tom Naylor and Sean Raggett are all available again for Pompey after returning to full training.
Jack Whatmough has also recovered from a knee injury, but is not yet ready to be considered for selection.
It leaves midfielder Bryn Morris (groin) as the only member of the Blues squad currently out of action.
Northampton played on Sunday and, like Pompey, are likely to make plenty of changes to their side.
HEAD TO HEAD
Pompey: 18 wins
Northampton: 10 wins
At Fratton Park
Pompey: 12 wins
Northampton: 3 wins
Pompey fans can secure seats online here or by visiting the Anson Road ticket office.
From 5.30pm this evening, they can also be bought from the ticket office in Frogmore Road.
Referee: Will Finnie
Assistants: Michael Webb and Adrian Tranter
Fourth Official: Adrian Quelch
Supporters in the UK and Ireland can watch the action live, with commentary, replays and graphics. It is priced £10 for a match pass.
Domestic subscribers will, as usual, be able to listen to listen to live commentary from Andy Moon and Guy Whittingham by signing into their account and visiting the match centre from 7pm.
Please note that domestic subscribers will still need to purchase a match pass in order to watch the game live.
Overseas subscribers and match pass holders can also watch the action, with commentary starting from around 10 minutes before kick-off.
Please note that in-stadium betting is no longer available at Fratton Park.
ALSO IN LEASING.COM TROPHY
Games kick-off at 7.45pm unless stated
Brighton U21 v Newport (7pm)
Colchester v Stevenage (7.30pm)
Shrewsbury v Manchester City U21 (7.30pm)
MK Dons v Coventry
Port Vale v Mansfield
Salford v Wolves U21
Walsall v Chelsea U21
Exeter v Oxford (7pm)
Peterborough v Ipswich (7.30pm)
Bristol Rovers v Leyton Orient
Doncaster v Leicester U21
Tranmere v Manchester United U21