Pompey will try to reclaim top spot in League One when they travel to current leaders Luton on Tuesday evening.
But it is the hosts who are the 11/8 favourites with Sky Bet to collect all three points at Kenilworth Road.
Kenny Jackett’s side can be backed at 19/10 to end the Hatters’ 16-game unbeaten league run, with the draw at 11/5.
The Blues triumphed 1-0 when the sides met at Fratton Park on the opening day of the season and a repeat of that scenario carries odds of 8/1.
Punters might instead be more tempted by a 2-1 victory at 10/1 or even a more convincing 3-1 win at 28/1.
Or you could hedge your bets by picking them to achieve success by either a 1-0, 2-0 or 2-1 scoreline at 11/4.
In the Request A Bet specials, the match containing over 4.5 goals, 15+ corners and 70+ booking points is on offer at 250/1.
Perhaps more realistic is both sides finding the target and securing at least three corners each at 11/8.
Jamal Lowe is back from suspension and the 6/1 favourite to net the opener, ahead of Ronan Curtis, Oli Hawkins and Brett Pitman at 13/2.
Elsewhere in the first goalscorer market, Louis Dennis, Gareth Evans and Matt Clarke are available at 17/2, 9/1 and 33/1 respectively.
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