The top two in League One meet in a blockbuster encounter at Kenilworth Road this evening (7.45pm kick-off).
Luton snatched top spot from Pompey’s grasp at the weekend, beating Southend while the Blues were in FA Cup action.
And Kenny Jackett’s side will aim to climb back to the summit by doing what no other side has managed this season.
The Hatters have yet to be beaten on home soil in the league this term, dropping just six points from 14 games.
No side comes close to the 35 goals scored on their own patch, while Barnsley are the only team to equal the nine goals they have conceded.
But Pompey can point to having the best away record in the division, with 30 points already collected on the road.
Luton do not appear to have suffered from the departure of manager Nathan Jones to Stoke earlier this month, with temporary boss Mick Harford yet to experience a league loss.
The Blues were beaten 1-0 when they visited Kenilworth Road for an FA Cup tie last term, although were 3-1 victors for a fourth tier clash the previous season.
It was Pompey who came out on top when the sides faced off at Fratton Park on the opening day of the current campaign, with Jamal Lowe netting the only goal of the game.
Pompey are waiting on international clearance to see whether loan signing Omar Bogle can make his debut.
Jamal Lowe returns from suspension, but Luke McGee (wrist) is injured and the game will likely come too soon for the fit-again pair of Oli Hawkins and Nathan Thompson.
Danny Hylton is unavailable for the hosts as he completes a four-match ban, while Glen Rea (knee) is injured and there are doubts over Harry Cornick (ankle) and Elliot Lee (hamstring).
HEAD TO HEAD
Pompey: 17 wins
Luton: 22 wins
At Kenilworth Road
Pompey: 4 wins
Luton: 18 wins
Pompey have sold their full allocation of tickets and no more will be available to buy at the ground.
Supporters collecting tickets at Kenilworth Road this evening can do so from the Oak Road turnstiles.
Click here to read a guide to the stadium for away fans.
Supporters in the UK and Ireland can watch the action live, with commentary and graphics. It is priced £10 for a match pass.
Please note that subscribers will still need to purchase a match pass in order to watch the game live.
Overseas subscribers and match pass holders can watch the action, with commentary starting from around 10 minutes before kick-off.
ALSO IN LEAGUE ONE
Blackpool v Wycombe
Bradford v Shrewsbury
Bristol Rovers v Peterborough
Gillingham v Accrington
Oxford v Barnsley