The top two in League One meet in a blockbuster encounter at Kenilworth Road this evening (7.45pm kick-off).
Luton snatched top spot from Pompey’s grasp at the weekend, beating Southend while the Blues were in FA Cup action.
And Kenny Jackett’s side will aim to climb back to the summit by doing what no other side has managed this season.
The Hatters have yet to be beaten on home soil in the league this term, dropping just six points from 14 games.
No side comes close to the 35 goals scored on their own patch, while Barnsley are the only team to equal the nine goals they have conceded.
But Pompey can point to having the best away record in the division, with 30 points already collected on the road.
Luton do not appear to have suffered from the departure of manager Nathan Jones to Stoke earlier this month, with temporary boss Mick Harford yet to experience a league loss.
The Blues were beaten 1-0 when they visited Kenilworth Road for an FA Cup tie last term, although were 3-1 victors for a fourth tier clash the previous season.
It was Pompey who came out on top when the sides faced off at Fratton Park on the opening day of the current campaign, with Jamal Lowe netting the only goal of the game.
TEAM NEWS
Pompey are waiting on international clearance to see whether loan signing Omar Bogle can make his debut.
Jamal Lowe returns from suspension, but Luke McGee (wrist) is injured and the game will likely come too soon for the fit-again pair of Oli Hawkins and Nathan Thompson.
Danny Hylton is unavailable for the hosts as he completes a four-match ban, while Glen Rea (knee) is injured and there are doubts over Harry Cornick (ankle) and Elliot Lee (hamstring).
VIEW FROM THE DRESSING ROOM
Read the thoughts of Joe Gallen and Gareth Evans or register for a free iFollow account to watch the below video.
HEAD TO HEAD
Overall
Pompey: 17 wins
Luton: 22 wins
13 draws
At Kenilworth Road
Pompey: 4 wins
Luton: 18 wins
5 draws
TICKETS
Pompey have sold their full allocation of tickets and no more will be available to buy at the ground.
Supporters collecting tickets at Kenilworth Road this evening can do so from the Oak Road turnstiles.
Click here to read a guide to the stadium for away fans.
MATCH COVERAGE
Supporters in the UK and Ireland can watch the action live, with commentary and graphics. It is priced £10 for a match pass.
Domestic subscribers will, as usual, be able to listen to listen to live commentary from Andy Moon and Guy Whittingham by signing into their account and visiting the match centre from 7pm.
Please note that subscribers will still need to purchase a match pass in order to watch the game live.
Overseas subscribers and match pass holders can watch the action, with commentary starting from around 10 minutes before kick-off.
Click here for more information about using iFollow on a matchday and click here for information on downloading the app, so you can access content on your mobile device.
We will have updates throughout the game on Twitter and the match centre. You can also see behind-the-scenes content on our Instagram story and Snapchat account.
There will be post-match reaction on the website, iFollow and our official YouTube channel, with highlights to follow on Wednesday.
Local listeners can hear commentary by tuning in to either Express FM or BBC Radio Solent.
BETTING
Luton are the 6/5 favourites with Sky Bet to secure all three points, while the visitors can be backed at 23/10.
Click here to read our full betting guide and visit www.skybet.com/pompey to earn money for the club when you place a bet. Please gamble responsibly.
ALSO IN LEAGUE ONE
Blackpool v Wycombe
Bradford v Shrewsbury
Bristol Rovers v Peterborough
Gillingham v Accrington
Oxford v Barnsley
LAST MEETING