Pompey return to the bread and butter of League One football after progressing in both the FA Cup and Checkatrade Trophy.
With promotion rivals Sunderland and Luton meeting this weekend, they could extend their advantage at the top of the table.
But Kenny Jackett’s side will have see off a Blackpool outfit who have proved a difficult team to breach this term.
The Seasiders have conceded just 25 goals in the league – fewer than any other side outside of the top five.
They are currently sitting in 11th position and are 10 points adrift of the play-off spots, but only eight clear of the drop zone.
Gary Bowyer stepped down as manager after the opening game and Terry McPhillips’ reign as his replacement began with a 2-1 defeat to Pompey at Bloomfield Road.
Their form improved dramatically from that point, but has tailed off in recent weeks, with five losses from the past seven league fixtures.
Blackpool’s last outing saw them beaten 3-0 by Arsenal on home soil in the FA Cup, while they were also knocked out of the Carabao Cup by the same opposition.
Lee Brown is set to return to training next week following a hamstring injury, so Saturday’s game comes too soon for the left-back.
Ben Close (ankle), Oli Hawkins (calf), Luke McGee (wrist) and Nathan Thompson (hamstring) are also sidelined, but new signing Andy Cannon could make his debut.
Blackpool have a doubt over first choice keeper Mark Howard (groin), with Max Clayton (hamstring), Mark Cullen (hamstring) Joe Dodoo (ankle) and Jimmy Ryan (knee) definitely missing.
HEAD TO HEAD
Pompey: 22 wins
Blackpool: 26 wins
At Fratton Park
Pompey: 15 wins
Blackpool: 10 wins
There is limited seating in the Milton End still available, so click here to secure your seat before they sell out.
Overseas subscribers and match pass holders can watch the action – now with on-screen graphics – and commentary will begin from around 10 minutes before kick-off.
ALSO IN LEAGUE ONE
Accrington v Bristol Rovers
Barnsley v Bradford
Burton v Gillingham
Coventry v AFC Wimbledon
Fleetwood v Oxford
Peterborough v Rochdale
Shrewsbury v Charlton
Southend v Plymouth
Sunderland v Luton
Walsall v Scunthorpe
Wycombe v Doncaster