Pompey will aim to continue their run in the Emirates FA Cup when they host QPR on Saturday (3pm kick-off).
It is the second round in succession that the Blues take on Championship opposition, following their dramatic victory at high-flying Norwich earlier this month.
The fourth round sees them on home soil, however, and facing a side currently sitting 14th in the second tier table.
Rangers have lost both league matches since beating Leeds 2-1 at Loftus Road to reach this stage of the competition.
Steve McClaren’s side suffered a heavy 4-1 home defeat to Preston last Saturday, with former Pompey loanee Jayden Stockley among the scorers for the visitors.
But they are still just seven points adrift of the play-off places, as they seek to improve on last term's 16th-place finish.
Pompey and QPR have – perhaps surprisingly – never previously met in the FA Cup and you have to go back to the 2010/11 campaign to find their most recent contests.
They played out a 1-1 draw at Fratton Park, with Liam Lawrence netting a penalty and getting dismissed in a game that saw both teams end with 10 men.
Pompey will be without the suspended Jamal Lowe, while Andy Cannon, Matt Casey and Dan Smith are all cup-tied having featured for other clubs earlier in the competition.
Oli Hawkins (calf), Luke McGee (wrist) and Nathan Thompson (hamstring) are still injured and there is a doubt over Louis Dennis (knee).
QPR are missing Geoff Cameron (ankle), Tomer Hemed (hernia) and Angel Rangel (thigh), with Australian midfielder Massimo Luongo currently away at the Asia Cup.
HEAD TO HEAD
Pompey: 10 wins
QPR: 14 wins
At Fratton Park
Pompey: 7 wins
QPR: 5 wins
There are a limited number of single seats still available for the tie, which can be bought online here or by visiting the Anson Road ticket office.
The tie has been selected for featured highlights, meaning there will be a number of broadcast vehicles at the game.
This means there will be fewer than 100 car parking spaces available for fans behind the North Stand. They are priced £10 each and allocated on a first come, first served basis.
Overseas subscribers should note that there is no live iFollow video coverage of FA Cup games, although audio commentary will be available.
ALSO IN EMIRATES FA CUP
Kick-off 3pm unless stated
Bristol City v Bolton (7.45pm)
Arsenal v Manchester United (7.55pm)
Accrington v Derby (12.30pm)
Brighton v West Brom
Doncaster v Oldham
Manchester City v Burnley
Middlesbrough v Newport
Newcastle v Watford
Shrewsbury v Wolves
Swansea v Gillingham
Millwall v Everton (5.30pm)
AFC Wimbledon v West Ham (7.45pm)
Crystal Palace v Tottenham (4pm)
Chelsea v Sheffield Wednesday (6pm)
Barnet v Brentford (7.45pm)
🎥 #ThrowbackThursday#Pompey's first league win of the 1998/99 season came against Saturday's @EmiratesFACup opponents @QPR 👇— Portsmouth FC (@officialpompey) January 24, 2019
It was John Aloisi with the dinked effort, @4AFMac with the header and Martin Phillips on target for the Blues' third goal to seal a fine victory 👌 pic.twitter.com/CcG6kFeUSc